7C2K

COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex

Summary for 7C2K

EMDB information30275
DescriptorRNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ... (6 entities in total)
Functional Keywordscovid-19, 2019-ncov, sars-cov-2, virus, rdrp, nsp12, nsp7, nsp8, rtc, cryo-em, viral protein, rna polymerase, drug target, antiviral, pre-translocated catalytic complex, viral protein-rna complex, viral protein/rna
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
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Total number of polymer chains6
Total molecular weight177127.99
Authors
Wang, Q.,Gao, Y.,Ji, W.,Mu, A.,Rao, Z. (deposition date: 2020-05-07, release date: 2020-06-03, Last modification date: 2020-08-05)
Primary citation
Wang, Q.,Wu, J.,Wang, H.,Gao, Y.,Liu, Q.,Mu, A.,Ji, W.,Yan, L.,Zhu, Y.,Zhu, C.,Fang, X.,Yang, X.,Huang, Y.,Gao, H.,Liu, F.,Ge, J.,Sun, Q.,Yang, X.,Xu, W.,Liu, Z.,Yang, H.,Lou, Z.,Jiang, B.,Guddat, L.W.,Gong, P.,Rao, Z.
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
Cell, 182:417-428.e13, 2020
PubMed: 32526208 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2020.05.034
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone700 0.52MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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171313
PDB entries from 2020-11-18