7C2K

COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RNA-directed RNA polymerase	polymer	944	108350.7	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP12,Pol,RdRp,Non-structural protein 12
2	B, D	Non-structural protein 8	polymer	200	22057.2	2	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP8-1,nsp8
3	C	Non-structural protein 7	polymer	85	9403.0	1	UniProt (P0DTD1) Pfam (PF08716) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP7
4	F	RNA (29-MER)	polymer	29	9293.5	1		Foot-and-mouth disease virus
5	G	RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*CP*AP*CP*AP*GP*G*(F86)P*G)-3')	polymer	18	5835.6	1		Foot-and-mouth disease virus
6	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met -1	-	expression tag
Gly 0	-	expression tag
His 933	-	expression tag
His 934	-	expression tag
His 935	-	expression tag
His 936	-	expression tag
His 937	-	expression tag
His 938	-	expression tag
His 939	-	expression tag
His 940	-	expression tag
His 941	-	expression tag
His 942	-	expression tag

B, D: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Gly -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	176997.2
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	177128.0

*Water molecules are not included.