Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin

Summary for 7D4F

EMDB information30572
DescriptorNon-structural protein 8, Non-structural protein 7, Non-structural protein 12, ... (5 entities in total)
Functional Keywordscovid-19, rna polymerase, suramin binding, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains4
Total molecular weight162815.84
Li, Z.,Yin, W.,Zhou, Z.,Yu, X.,Xu, H. (deposition date: 2020-09-23, release date: 2020-11-11)
Primary citation
Yin, W.,Luan, X.,Li, Z.,Zhang, L.,Zhou, Z.,Gao, M.,Wang, X.,Zhou, F.,Wang, Q.,Wang, Q.,Jiang, Y.,Jiang, H.,Xiao, G.,Yu, X.,Zhang, S.,Xu, H.
Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19
To Be Published,
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers50 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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PDB entries from 2020-11-25