7D4F

Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, G	Non-structural protein 8	polymer	199	22034.2	2	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	nsp8
2	C	Non-structural protein 7	polymer	84	9380.0	1	UniProt (P0DTD1) Pfam (PF08716) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	nsp7
3	A	RNA-directed RNA polymerase	polymer	943	107965.3	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	Pol,RdRp,Non-structural protein 12,nsp12
4	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A	8-(3-(3-aminobenzamido)-4-methylbenzamido)naphthalene-1,3,5-trisulfonic acid	non-polymer		635.6	2	Chemie (H3U)

Sequence modifications

B, G: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

A: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 933	-	expression tag
Gly 934	-	expression tag
Ser 935	-	expression tag
Glu 936	-	expression tag
Asn 937	-	expression tag
Leu 938	-	expression tag
Tyr 939	-	expression tag
Phe 940	-	expression tag
Gln 941	-	expression tag
Gly 942	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	161413.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1402.1
All*	Total formula weight	162815.8

*Water molecules are not included.