7CYQ

Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis

Summary for 7CYQ

• Entry DOI: 10.2210/pdb7cyq/pdb
• EMDB information: 30504
• Descriptor: RNA-directed RNA polymerase, MAGNESIUM ION, Non-structural protein 8, ... (10 entities in total)
• Functional Keywords: sars-cov-2, transcription and replication, nsp9, nsp13, nsp12-nsp7-nsp8, viral protein-rna complex, viral protein/rna
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 9
• Total formula weight: 338376.40

Authors

Yan, L.,Ge, J.,Zheng, L.,Zhang, Y.,Gao, Y.,Wang, T.,Wang, H.,Huang, Y.,Li, M.,Wang, Q.,Rao, Z.,Lou, Z. (deposition date: 2020-09-04, release date: 2020-12-09, Last modification date: 2024-03-27)

• Primary citation: Yan, L.,Ge, J.,Zheng, L.,Zhang, Y.,Gao, Y.,Wang, T.,Huang, Y.,Yang, Y.,Gao, S.,Li, M.,Liu, Z.,Wang, H.,Li, Y.,Chen, Y.,Guddat, L.W.,Wang, Q.,Rao, Z.,Lou, Z.; Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.; Cell, 184:184-193.e10, 2021; PubMed: 33232691; DOI: 10.1016/j.cell.2020.11.016

Experimental method

ELECTRON MICROSCOPY (2.83 Å)