7B3B

Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1)

Summary for 7B3B

Entry DOI	10.2210/pdb7b3b/pdb
EMDB information	11993 11994 11995
Descriptor	RNA-directed RNA polymerase nsp12, Non-structural protein 8, Non-structural protein 7, ... (6 entities in total)
Functional Keywords	sars-cov-2, polymerase, transcription, replication, rna, remdesivir, inhibition, nucleotide analogue, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	5
Total formula weight	161851.01
Authors	Kokic, G.,Hillen, H.S.,Tegunov, D.,Dienemann, C.,Seitz, F.,Schmitzova, J.,Farnung, L.,Siewert, A.,Hoebartner, C.,Cramer, P. (deposition date: 2020-11-30, release date: 2020-12-23, Last modification date: 2022-07-27)
Primary citation	Kokic, G.,Hillen, H.S.,Tegunov, D.,Dienemann, C.,Seitz, F.,Schmitzova, J.,Farnung, L.,Siewert, A.,Hobartner, C.,Cramer, P. Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun, 12:279-279, 2021 Cited by PubMed: 33436624 DOI: 10.1038/s41467-020-20542-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation