7CTT

Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state.

Summary for 7CTT

• Entry DOI: 10.2210/pdb7ctt/pdb
• EMDB information: 30469
• Descriptor: RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ... (8 entities in total)
• Functional Keywords: polymerase, replication, inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 179545.45

Authors

Peng, Q.,Peng, R.,Shi, Y. (deposition date: 2020-08-20, release date: 2020-09-02, Last modification date: 2024-05-29)

• Primary citation: Peng, Q.,Peng, R.,Yuan, B.,Wang, M.,Zhao, J.,Fu, L.,Qi, J.,Shi, Y.; Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir.; Innovation (N Y), 2:100080-100080, 2021; PubMed: 33521757; DOI: 10.1016/j.xinn.2021.100080

Experimental method

ELECTRON MICROSCOPY (3.2 Å)