7CTT
Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-directed RNA polymerase | polymer | 932 | 106781.0 | 1 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | pp1ab,ORF1ab polyprotein,Pol,RdRp,Non-structural protein 12,nsp12 |
| 2 | B, D (B, D) | Non-structural protein 8 | polymer | 198 | 21903.0 | 2 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | pp1ab,ORF1ab polyprotein,nsp8 |
| 3 | C (C) | Non-structural protein 7 | polymer | 83 | 9248.8 | 1 | UniProt (P0DTD1) Pfam (PF08716) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | pp1ab,ORF1ab polyprotein,nsp7 |
| 4 | E (Q) | Primer-RNA (5'-R(P*UP*UP*CP*UP*CP*CP*UP*AP*AP*GP*AP*AP*GP*CP*UP*A)-3') | polymer | 20 | 6328.8 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 5 | F (T) | Template-RNA (5'-R(P*AP*CP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*GP*GP*AP*GP*AP*A)-3') | polymer | 40 | 12696.5 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 6 | G, H (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | I (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 8 | J (A) | [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonyl-5-fluoranyl-2-oxidanylidene-pyrazin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 529.2 | 1 | Chemie (GE6) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 178861.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 684.3 | |
| All* | Total formula weight | 179545.5 |
