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8SEL	Type IIIb beta-amyloid 40 Filaments from Down Syndrome Descriptor: Amyloid-beta protein 40 Authors: Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W. Deposit date: 2023-04-10 Release date: 2024-04-03 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome. Nat.Struct.Mol.Biol., 31, 2024
5MYK	Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb Descriptor: Amyloid beta A4 protein, Fab c#17 heavy chain, Fab c#17 light chain Authors: Parthier, C, Piechotta, A, Stubbs, M.T. Deposit date: 2017-01-26 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
6WXM	X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 16-36 Descriptor: Amyloid-beta protein, HEXANE-1,6-DIOL Authors: Kreutzer, A.G, Nowick, J.S. Deposit date: 2020-05-11 Release date: 2020-07-08 Last modified: 2020-08-26 Method: X-RAY DIFFRACTION (2.3 Å) Cite: X-ray Crystallography Reveals Parallel and Antiparallel beta-Sheet Dimers of a beta-Hairpin Derived from A beta16-36that Assemble to Form Different Tetramers. Acs Chem Neurosci, 11, 2020
6NB9	Amyloid-Beta (20-34) with L-isoaspartate 23 Descriptor: Amyloid-beta A4 protein Authors: Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. Deposit date: 2018-12-06 Release date: 2019-08-07 Last modified: 2022-09-07 Method: ELECTRON CRYSTALLOGRAPHY (1.05 Å) Cite: Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
7F29	Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42) Descriptor: ACETIC ACID, Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose Authors: Xia, W.C, Sun, Y.P, Liu, C. Deposit date: 2021-06-10 Release date: 2022-07-13 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation J.Am.Chem.Soc., 143, 2021
5HOY	X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV). Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) Authors: Kreutzer, A.G, Spencer, R.K, Nowick, J.S. Deposit date: 2016-01-19 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.295 Å) Cite: X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
6OIZ	Amyloid-Beta (20-34) wild type Descriptor: Amyloid beta A4 protein Authors: Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S. Deposit date: 2019-04-10 Release date: 2019-08-07 Last modified: 2024-05-15 Method: ELECTRON CRYSTALLOGRAPHY (1.1 Å) Cite: Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun, 10, 2019
6OC9	S8 phosphorylated beta amyloid 40 fibrils Descriptor: Amyloid-beta precursor protein, PHOSPHONATE Authors: Qiang, W, Hu, Z.W. Deposit date: 2019-03-22 Release date: 2019-06-05 Last modified: 2024-05-01 Method: SOLID-STATE NMR Cite: Molecular structure of an N-terminal phosphorylated beta-amyloid fibril. Proc.Natl.Acad.Sci.USA, 116, 2019
5MYX	Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18 Descriptor: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18 Authors: Parthier, C, Piechotta, A, Stubbs, M.T. Deposit date: 2017-01-30 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.492 Å) Cite: Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
7JXO	Triangular trimer of beta-hairpins derived from Abeta17-36 with an F20Cha mutation Descriptor: Amyloid-beta 17-36 peptide Authors: Kreutzer, A.G, Haerianardakani, S, Nowick, J.S. Deposit date: 2020-08-27 Release date: 2020-12-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by beta-Hairpins Derived from A beta. J.Am.Chem.Soc., 142, 2020
5HOW	X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V Descriptor: Amyloid beta A4 protein Authors: Kreutzer, A.G, Nowick, J.S, Spencer, R.K. Deposit date: 2016-01-19 Release date: 2016-03-23 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (2.295 Å) Cite: X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
5HOX	X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV). Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) Authors: Kreutzer, A.G, Nowick, J.S, Spencer, R.K. Deposit date: 2016-01-19 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin. J.Am.Chem.Soc., 138, 2016
5OQV	Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM Descriptor: Amyloid beta A4 protein Authors: Gremer, L, Schoelzel, D, Schenk, C, Reinartz, E, Labahn, J, Ravelli, R, Tusche, M, Lopez-Iglesias, C, Hoyer, W, Heise, H, Willbold, D, Schroeder, G.F. Deposit date: 2017-08-14 Release date: 2017-09-13 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4 Å) Cite: Fibril structure of amyloid-beta (1-42) by cryo-electron microscopy. Science, 358, 2017
7JXN	Beta hairpin derived from Abeta17-36 with an F20Cha mutation Descriptor: Amyloid-beta 17-36 peptide, CHLORIDE ION, SODIUM ION Authors: Kreutzer, A.G, Haerianardakani, S, Nowick, J.S. Deposit date: 2020-08-27 Release date: 2020-12-09 Last modified: 2020-12-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by beta-Hairpins Derived from A beta. J.Am.Chem.Soc., 142, 2020
8EZD	Brain-derived 42-residue amyloid-beta fibril type A Descriptor: Beta-amyloid protein 42 Authors: Tycko, R, Lee, M, Yau, Y.-M, Louis, J.M. Deposit date: 2022-10-31 Release date: 2023-03-22 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions. Proc.Natl.Acad.Sci.USA, 120, 2023
8EZE	Brain-derived 42-residue amyloid-beta fibril type B Descriptor: Beta-amyloid protein 42 Authors: Tycko, R, Lee, M, Yau, Y.-M, Louis, J.M. Deposit date: 2022-10-31 Release date: 2023-03-22 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions. Proc.Natl.Acad.Sci.USA, 120, 2023
8FF2	Amyloid-beta (1-40) fibrils derived from a CAA patient Descriptor: Amyloid-beta precursor protein Authors: Crooks, E.J, Fu, Z, Chowdhury, S, Smith, S.O. Deposit date: 2022-12-07 Release date: 2023-12-06 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.87 Å) Cite: An electrostatic cluster guides A beta 40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy. J.Struct.Biol., 216, 2024
8FF3	Amyloid-beta (1-40) fibrils derived from familial Dutch-type CAA patient (population B) Descriptor: Amyloid-beta precursor protein Authors: Crooks, E.J, Fu, Z, Chowdury, S, Smith, S.O. Deposit date: 2022-12-07 Release date: 2023-12-06 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: An electrostatic cluster guides A beta 40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy. J.Struct.Biol., 216, 2024
6YHF	Solution NMR Structure of APP TMD Descriptor: Amyloid-beta precursor protein Authors: Silber, M, Muhle-Goll, C. Deposit date: 2020-03-29 Release date: 2020-12-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6YHO	Solution NMR Structure of APP G38P mutant TM Descriptor: Amyloid-beta precursor protein G38P mutant Authors: Silber, M, Muhle-Goll, C. Deposit date: 2020-03-30 Release date: 2020-12-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6YHP	Solution NMR Structure of APP V44M mutant TMD Descriptor: Amyloid-beta precursor protein V44M mutant Authors: Silber, M, Muhle-Goll, C. Deposit date: 2020-03-30 Release date: 2020-12-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6YHX	Solution NMR Structure of APP I45T mutant TMD Descriptor: Amyloid-beta precursor protein I45T mutant Authors: Silber, M, Muhle-Goll, C. Deposit date: 2020-03-31 Release date: 2020-12-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6SHS	Abeta fibril (Morphology I) Descriptor: Amyloid-beta precursor protein Authors: Kollmer, M, Fandrich, M. Deposit date: 2019-08-08 Release date: 2019-11-06 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Cryo-EM structure and polymorphism of A beta amyloid fibrils purified from Alzheimer's brain tissue. Nat Commun, 10, 2019
6YHI	Solution NMR Structure of APP G38L mutant TMD Descriptor: Amyloid-beta precursor protein G38L mutant Authors: Silber, M, Muhle-Goll, C. Deposit date: 2020-03-30 Release date: 2020-12-09 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of gamma-Secretase. Acs Chem Neurosci, 11, 2020
6SZF	Solution structure of the amyloid beta-peptide (1-42) Descriptor: Amyloid-beta precursor protein Authors: Grimaldi, M, Santoro, A, Stillitano, I, Buonocore, M, D'Ursi, A.M. Deposit date: 2019-10-02 Release date: 2020-10-14 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Exploring the Early Stages of the Amyloid A beta (1-42) Peptide Aggregation Process: An NMR Study. Pharmaceuticals, 14, 2021

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