8SEL
Type IIIb beta-amyloid 40 Filaments from Down Syndrome
Summary for 8SEL
Entry DOI | 10.2210/pdb8sel/pdb |
EMDB information | 40421 |
Descriptor | Amyloid-beta protein 40 (1 entity in total) |
Functional Keywords | beta amyloid filaments, down syndrome, neuropeptide, human trisomy 21 |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 20 |
Total formula weight | 86717.04 |
Authors | Hoq, M.R.,Vago, F.S.,Bharath, S.R.,Jiang, W. (deposition date: 2023-04-10, release date: 2024-04-03, Last modification date: 2024-06-26) |
Primary citation | Fernandez, A.,Hoq, M.R.,Hallinan, G.I.,Li, D.,Bharath, S.R.,Vago, F.S.,Zhang, X.,Ozcan, K.A.,Newell, K.L.,Garringer, H.J.,Jiang, W.,Ghetti, B.,Vidal, R. Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome. Nat.Struct.Mol.Biol., 31:903-909, 2024 Cited by PubMed: 38553642DOI: 10.1038/s41594-024-01252-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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