8SEL

Type IIIb beta-amyloid 40 Filaments from Down Syndrome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
A	HIS6
E	HIS14
F	HIS6
F	HIS14
G	HIS6
G	HIS14
H	HIS6
H	HIS14
I	HIS6
I	HIS14
J	HIS6
A	HIS14
J	HIS14
K	HIS6
K	HIS14
L	HIS6
L	HIS14
M	HIS6
M	HIS14
N	HIS6
N	HIS14
O	HIS6
B	HIS6
O	HIS14
P	HIS6
P	HIS14
Q	HIS6
Q	HIS14
R	HIS6
R	HIS14
S	HIS6
S	HIS14
T	HIS6
B	HIS14
T	HIS14
C	HIS6
C	HIS14
D	HIS6
D	HIS14
E	HIS6

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207

Chain	Residue	Details
A	TYR10
J	TYR10
K	TYR10
L	TYR10
M	TYR10
N	TYR10
O	TYR10
P	TYR10
Q	TYR10
R	TYR10
S	TYR10
B	TYR10
T	TYR10
C	TYR10
D	TYR10
E	TYR10
F	TYR10
G	TYR10
H	TYR10
I	TYR10

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
A	HIS13
J	HIS13
K	HIS13
L	HIS13
M	HIS13
N	HIS13
O	HIS13
P	HIS13
Q	HIS13
R	HIS13
S	HIS13
B	HIS13
T	HIS13
C	HIS13
D	HIS13
E	HIS13
F	HIS13
G	HIS13
H	HIS13
I	HIS13

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671

Chain	Residue	Details
A	ASP1
J	ASP1
K	ASP1
L	ASP1
M	ASP1
N	ASP1
O	ASP1
P	ASP1
Q	ASP1
R	ASP1
S	ASP1
B	ASP1
T	ASP1
C	ASP1
D	ASP1
E	ASP1
F	ASP1
G	ASP1
H	ASP1
I	ASP1

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999

Chain	Residue	Details
A	ASP7
J	ASP7
K	ASP7
L	ASP7
M	ASP7
N	ASP7
O	ASP7
P	ASP7
Q	ASP7
R	ASP7
S	ASP7
B	ASP7
T	ASP7
C	ASP7
D	ASP7
E	ASP7
F	ASP7
G	ASP7
H	ASP7
I	ASP7

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430

Chain	Residue	Details
A	LYS16
J	LYS16
K	LYS16
L	LYS16
M	LYS16
N	LYS16
O	LYS16
P	LYS16
Q	LYS16
R	LYS16
S	LYS16
B	LYS16
T	LYS16
C	LYS16
D	LYS16
E	LYS16
F	LYS16
G	LYS16
H	LYS16
I	LYS16

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112

Chain	Residue	Details
A	PHE19
J	PHE19
K	PHE19
L	PHE19
M	PHE19
N	PHE19
O	PHE19
P	PHE19
Q	PHE19
R	PHE19
S	PHE19
B	PHE19
T	PHE19
C	PHE19
D	PHE19
E	PHE19
F	PHE19
G	PHE19
H	PHE19
I	PHE19

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	SITE: Implicated in free radical propagation => ECO:0000250

Chain	Residue	Details
A	GLY33
J	GLY33
K	GLY33
L	GLY33
M	GLY33
N	GLY33
O	GLY33
P	GLY33
Q	GLY33
R	GLY33
S	GLY33
B	GLY33
T	GLY33
C	GLY33
D	GLY33
E	GLY33
F	GLY33
G	GLY33
H	GLY33
I	GLY33

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332

Chain	Residue	Details
A	MET35
J	MET35
K	MET35
L	MET35
M	MET35
N	MET35
O	MET35
P	MET35
Q	MET35
R	MET35
S	MET35
B	MET35
T	MET35
C	MET35
D	MET35
E	MET35
F	MET35
G	MET35
H	MET35
I	MET35

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430

Chain	Residue	Details
A	VAL40
J	VAL40
K	VAL40
L	VAL40
M	VAL40
N	VAL40
O	VAL40
P	VAL40
Q	VAL40
R	VAL40
S	VAL40
B	VAL40
T	VAL40
C	VAL40
D	VAL40
E	VAL40
F	VAL40
G	VAL40
H	VAL40
I	VAL40

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872

Chain	Residue	Details
A	TYR10
J	TYR10
K	TYR10
L	TYR10
M	TYR10
N	TYR10
O	TYR10
P	TYR10
Q	TYR10
R	TYR10
S	TYR10
B	TYR10
T	TYR10
C	TYR10
D	TYR10
E	TYR10
F	TYR10
G	TYR10
H	TYR10
I	TYR10

---