8SEL
Type IIIb beta-amyloid 40 Filaments from Down Syndrome
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016020 | cellular_component | membrane |
B | 0016020 | cellular_component | membrane |
C | 0016020 | cellular_component | membrane |
D | 0016020 | cellular_component | membrane |
E | 0016020 | cellular_component | membrane |
F | 0016020 | cellular_component | membrane |
G | 0016020 | cellular_component | membrane |
H | 0016020 | cellular_component | membrane |
I | 0016020 | cellular_component | membrane |
J | 0016020 | cellular_component | membrane |
K | 0016020 | cellular_component | membrane |
L | 0016020 | cellular_component | membrane |
M | 0016020 | cellular_component | membrane |
N | 0016020 | cellular_component | membrane |
O | 0016020 | cellular_component | membrane |
P | 0016020 | cellular_component | membrane |
Q | 0016020 | cellular_component | membrane |
R | 0016020 | cellular_component | membrane |
S | 0016020 | cellular_component | membrane |
T | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 40 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
Chain | Residue | Details |
A | HIS6 | |
E | HIS14 | |
F | HIS6 | |
F | HIS14 | |
G | HIS6 | |
G | HIS14 | |
H | HIS6 | |
H | HIS14 | |
I | HIS6 | |
I | HIS14 | |
J | HIS6 | |
A | HIS14 | |
J | HIS14 | |
K | HIS6 | |
K | HIS14 | |
L | HIS6 | |
L | HIS14 | |
M | HIS6 | |
M | HIS14 | |
N | HIS6 | |
N | HIS14 | |
O | HIS6 | |
B | HIS6 | |
O | HIS14 | |
P | HIS6 | |
P | HIS14 | |
Q | HIS6 | |
Q | HIS14 | |
R | HIS6 | |
R | HIS14 | |
S | HIS6 | |
S | HIS14 | |
T | HIS6 | |
B | HIS14 | |
T | HIS14 | |
C | HIS6 | |
C | HIS14 | |
D | HIS6 | |
D | HIS14 | |
E | HIS6 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
Chain | Residue | Details |
A | TYR10 | |
J | TYR10 | |
K | TYR10 | |
L | TYR10 | |
M | TYR10 | |
N | TYR10 | |
O | TYR10 | |
P | TYR10 | |
Q | TYR10 | |
R | TYR10 | |
S | TYR10 | |
B | TYR10 | |
T | TYR10 | |
C | TYR10 | |
D | TYR10 | |
E | TYR10 | |
F | TYR10 | |
G | TYR10 | |
H | TYR10 | |
I | TYR10 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
Chain | Residue | Details |
A | HIS13 | |
J | HIS13 | |
K | HIS13 | |
L | HIS13 | |
M | HIS13 | |
N | HIS13 | |
O | HIS13 | |
P | HIS13 | |
Q | HIS13 | |
R | HIS13 | |
S | HIS13 | |
B | HIS13 | |
T | HIS13 | |
C | HIS13 | |
D | HIS13 | |
E | HIS13 | |
F | HIS13 | |
G | HIS13 | |
H | HIS13 | |
I | HIS13 |
site_id | SWS_FT_FI4 |
Number of Residues | 20 |
Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
Chain | Residue | Details |
A | ASP1 | |
J | ASP1 | |
K | ASP1 | |
L | ASP1 | |
M | ASP1 | |
N | ASP1 | |
O | ASP1 | |
P | ASP1 | |
Q | ASP1 | |
R | ASP1 | |
S | ASP1 | |
B | ASP1 | |
T | ASP1 | |
C | ASP1 | |
D | ASP1 | |
E | ASP1 | |
F | ASP1 | |
G | ASP1 | |
H | ASP1 | |
I | ASP1 |
site_id | SWS_FT_FI5 |
Number of Residues | 20 |
Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
Chain | Residue | Details |
A | ASP7 | |
J | ASP7 | |
K | ASP7 | |
L | ASP7 | |
M | ASP7 | |
N | ASP7 | |
O | ASP7 | |
P | ASP7 | |
Q | ASP7 | |
R | ASP7 | |
S | ASP7 | |
B | ASP7 | |
T | ASP7 | |
C | ASP7 | |
D | ASP7 | |
E | ASP7 | |
F | ASP7 | |
G | ASP7 | |
H | ASP7 | |
I | ASP7 |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
Chain | Residue | Details |
A | LYS16 | |
J | LYS16 | |
K | LYS16 | |
L | LYS16 | |
M | LYS16 | |
N | LYS16 | |
O | LYS16 | |
P | LYS16 | |
Q | LYS16 | |
R | LYS16 | |
S | LYS16 | |
B | LYS16 | |
T | LYS16 | |
C | LYS16 | |
D | LYS16 | |
E | LYS16 | |
F | LYS16 | |
G | LYS16 | |
H | LYS16 | |
I | LYS16 |
site_id | SWS_FT_FI7 |
Number of Residues | 20 |
Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
Chain | Residue | Details |
A | PHE19 | |
J | PHE19 | |
K | PHE19 | |
L | PHE19 | |
M | PHE19 | |
N | PHE19 | |
O | PHE19 | |
P | PHE19 | |
Q | PHE19 | |
R | PHE19 | |
S | PHE19 | |
B | PHE19 | |
T | PHE19 | |
C | PHE19 | |
D | PHE19 | |
E | PHE19 | |
F | PHE19 | |
G | PHE19 | |
H | PHE19 | |
I | PHE19 |
site_id | SWS_FT_FI8 |
Number of Residues | 20 |
Details | SITE: Implicated in free radical propagation => ECO:0000250 |
Chain | Residue | Details |
A | GLY33 | |
J | GLY33 | |
K | GLY33 | |
L | GLY33 | |
M | GLY33 | |
N | GLY33 | |
O | GLY33 | |
P | GLY33 | |
Q | GLY33 | |
R | GLY33 | |
S | GLY33 | |
B | GLY33 | |
T | GLY33 | |
C | GLY33 | |
D | GLY33 | |
E | GLY33 | |
F | GLY33 | |
G | GLY33 | |
H | GLY33 | |
I | GLY33 |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332 |
Chain | Residue | Details |
A | MET35 | |
J | MET35 | |
K | MET35 | |
L | MET35 | |
M | MET35 | |
N | MET35 | |
O | MET35 | |
P | MET35 | |
Q | MET35 | |
R | MET35 | |
S | MET35 | |
B | MET35 | |
T | MET35 | |
C | MET35 | |
D | MET35 | |
E | MET35 | |
F | MET35 | |
G | MET35 | |
H | MET35 | |
I | MET35 |
site_id | SWS_FT_FI10 |
Number of Residues | 20 |
Details | SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430 |
Chain | Residue | Details |
A | VAL40 | |
J | VAL40 | |
K | VAL40 | |
L | VAL40 | |
M | VAL40 | |
N | VAL40 | |
O | VAL40 | |
P | VAL40 | |
Q | VAL40 | |
R | VAL40 | |
S | VAL40 | |
B | VAL40 | |
T | VAL40 | |
C | VAL40 | |
D | VAL40 | |
E | VAL40 | |
F | VAL40 | |
G | VAL40 | |
H | VAL40 | |
I | VAL40 |
site_id | SWS_FT_FI11 |
Number of Residues | 20 |
Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
Chain | Residue | Details |
A | TYR10 | |
J | TYR10 | |
K | TYR10 | |
L | TYR10 | |
M | TYR10 | |
N | TYR10 | |
O | TYR10 | |
P | TYR10 | |
Q | TYR10 | |
R | TYR10 | |
S | TYR10 | |
B | TYR10 | |
T | TYR10 | |
C | TYR10 | |
D | TYR10 | |
E | TYR10 | |
F | TYR10 | |
G | TYR10 | |
H | TYR10 | |
I | TYR10 |