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6D3O
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BU of 6d3o by Molmil
Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with HH4, an alpha/beta-Peptide with Irregular Secondary Structure
Descriptor: HH4 alpha/beta-Peptide, Vascular endothelial growth factor A
Authors:Thomas, N.C, Forest, K.T, Gellman, S.H.
Deposit date:2018-04-16
Release date:2019-04-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:High-Resolution Structures for a Complex Between a Non-Helical Foldamer and VEGF
To Be Published
4ZFF
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BU of 4zff by Molmil
Dual-acting Fab 5A12 in complex with VEGF
Descriptor: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ...
Authors:Harris, S.F, Wu, P.
Deposit date:2015-04-21
Release date:2015-07-01
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
4WPB
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BU of 4wpb by Molmil
Vascular endothelial growth factor in complex with alpha/beta-VEGF-1
Descriptor: Vascular endothelial growth factor A, alpha/beta-VEGF-1
Authors:Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T.
Deposit date:2014-10-17
Release date:2015-04-15
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold.
Proc.Natl.Acad.Sci.USA, 112, 2015
1KAT
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BU of 1kat by Molmil
Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
Descriptor: Phage-Derived Peptide Antagonist, Vascular Endothelial Growth Factor
Authors:Pan, B, Li, B, Russell, S.J, Tom, J.Y.K, Cochran, A.G, Fairbrother, W.J.
Deposit date:2001-11-02
Release date:2002-11-02
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
J.Mol.Biol., 316, 2002
1BJ1
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BU of 1bj1 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
Descriptor: Fab fragment, heavy chain, light chain, ...
Authors:Muller, Y.A, Christinger, H.W, De Vos, A.M.
Deposit date:1998-06-30
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
3S1B
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BU of 3s1b by Molmil
The Development of Peptide-based Tools for the Analysis of Angiogenesis
Descriptor: Vascular endothelial growth factor A, mini-Z
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2011-05-14
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011
3S1K
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BU of 3s1k by Molmil
The Development of Peptide-based Tools for the Analysis of Angiogenesis
Descriptor: Vascular endothelial growth factor A, Z-domain
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2011-05-15
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011
3P9W
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BU of 3p9w by Molmil
Crystal structure of an engineered human autonomous VH Domain in complex with VEGF
Descriptor: Vascular endothelial growth factor A, human VEGF
Authors:Ma, X, Wiesmann, C.
Deposit date:2010-10-18
Release date:2012-04-18
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.
J.Mol.Biol., 425, 2013
4QCI
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BU of 4qci by Molmil
PDGF-B blocking antibody bound to PDGF-BB
Descriptor: Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain
Authors:Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G.
Deposit date:2014-05-12
Release date:2015-03-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
5HHD
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BU of 5hhd by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21
Descriptor: D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ...
Authors:Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
2C7W
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BU of 2c7w by Molmil
Crystal Structure of human vascular endothelial growth factor-B: Identification of amino acids important for angiogeninc activity
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
Authors:Iyer, S, Scotney, P.D, Nash, A.D, Acharya, K.R.
Deposit date:2005-11-29
Release date:2007-01-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
J.Mol.Biol., 359, 2006
2FJG
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BU of 2fjg by Molmil
Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
Descriptor: Fab heavy chain, Fab light chain, SULFATE ION, ...
Authors:Wiesmann, C.
Deposit date:2006-01-02
Release date:2006-02-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2XV7
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BU of 2xv7 by Molmil
Crystal structure of vascular endothelial growth factor D
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR D, alpha-D-mannopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Leppanen, V.-M, Jeltsch, M, Anisimov, A, Tvorogov, D, Aho, K, Kalkkinen, N, Toivanen, P, Yla-Herttuala, S, Ballmer-Hofer, K, Alitalo, K.
Deposit date:2010-10-23
Release date:2011-01-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Determinants of Vascular Endothelial Growth Factor-D - Receptor Binding and Specificity.
Blood, 117, 2011
5HHC
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BU of 5hhc by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n
Descriptor: D- Vascular endothelial growth factor-A, GLYCEROL, Vascular endothelial growth factor A
Authors:Uppalapati, M, Lee, D.J, Mandal, K, Kent, S.B.H, Sidhu, S.
Deposit date:2016-01-10
Release date:2016-03-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
Acs Chem.Biol., 11, 2016
4GLN
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BU of 4gln by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n
Descriptor: D-RFX001, Vascular endothelial growth factor A
Authors:Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
3BDY
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BU of 3bdy by Molmil
Dual specific bH1 Fab in complex with VEGF
Descriptor: Fab Fragment -Heavy Chain, Fab Fragment -Light Chain, GLYCEROL, ...
Authors:Bostrom, J.M, Wiesmann, C, Appleton, B.A.
Deposit date:2007-11-15
Release date:2008-11-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
3QTK
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BU of 3qtk by Molmil
The crystal structure of chemically synthesized VEGF-A
Descriptor: ACETATE ION, GLYCEROL, Vascular endothelial growth factor A, ...
Authors:Mandal, K, Kent, S.B.H.
Deposit date:2011-02-22
Release date:2011-07-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Total chemical synthesis of biologically active vascular endothelial growth factor.
Angew.Chem.Int.Ed.Engl., 50, 2011
4GLS
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BU of 4gls by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21
Descriptor: D- RFX001, D- Vascular endothelial growth factor-A, DI(HYDROXYETHYL)ETHER, ...
Authors:Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
5FV2
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BU of 5fv2 by Molmil
Crystal structure of hVEGF in complex with VH domain antibody
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR, VH DOMAIN ANTIBODY
Authors:Chung, C, Batuwangala, T.
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
5FV1
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BU of 5fv1 by Molmil
Crystal structure of hVEGF in complex with VK domain antibody
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR A, VK DOMAIN ANTIBODY
Authors:Chung, C, Walker, A.
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
2GNN
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BU of 2gnn by Molmil
Crystal Structure of the Orf Virus NZ2 Variant of VEGF-E
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ...
Authors:Prota, A.E, Pieren, M, Wagner, A, Kostrewa, D, Winkler, F.K, Ballmer-Hofer, K.
Deposit date:2006-04-10
Release date:2006-05-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.
J.Biol.Chem., 281, 2006
2FJH
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BU of 2fjh by Molmil
Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
Descriptor: Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A
Authors:Wiesmann, C.
Deposit date:2006-01-02
Release date:2006-02-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
1WQ8
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BU of 1wq8 by Molmil
Crystal structure of Vammin, a VEGF-F from a snake venom
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Vascular endothelial growth factor toxin
Authors:Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
Deposit date:2004-09-23
Release date:2004-12-07
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
1CZ8
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BU of 1cz8 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Descriptor: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ...
Authors:Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B.
Deposit date:1999-09-01
Release date:2000-03-20
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
4HQX
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BU of 4hqx by Molmil
CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)
Descriptor: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
Authors:Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012

 

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數據於2024-09-18公開中

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