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1WQ9
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BU of 1wq9 by Molmil
Crystal structure of VR-1, a VEGF-F from a snake venom
Descriptor: Vascular endothelial growth factor
Authors:Suto, K, Yamazaki, Y, Morita, T, Mizuno, H.
Deposit date:2004-09-24
Release date:2004-12-07
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
6D3O
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BU of 6d3o by Molmil
Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with HH4, an alpha/beta-Peptide with Irregular Secondary Structure
Descriptor: HH4 alpha/beta-Peptide, Vascular endothelial growth factor A
Authors:Thomas, N.C, Forest, K.T, Gellman, S.H.
Deposit date:2018-04-16
Release date:2019-04-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:High-Resolution Structures for a Complex Between a Non-Helical Foldamer and VEGF
To Be Published
4KZN
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BU of 4kzn by Molmil
crystal structure of human VEGF-A receptor binding domain
Descriptor: SULFATE ION, TRIETHYLENE GLYCOL, Vascular endothelial growth factor A, ...
Authors:Liaw, Y.C.
Deposit date:2013-05-30
Release date:2014-06-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7114 Å)
Cite:Structural Basis for the Bivalent Glycosylated Human VEGF-A121 and VEGF-A165 in recruiment of Receptor and Co-receptor
to be published
3BDY
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BU of 3bdy by Molmil
Dual specific bH1 Fab in complex with VEGF
Descriptor: Fab Fragment -Heavy Chain, Fab Fragment -Light Chain, GLYCEROL, ...
Authors:Bostrom, J.M, Wiesmann, C, Appleton, B.A.
Deposit date:2007-11-15
Release date:2008-11-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
2QR0
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BU of 2qr0 by Molmil
Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs
Descriptor: Fab-Fragment Heavy Chain, Fab-Fragment Light Chain, Vascular endothelial growth factor A
Authors:Wiesmann, C.
Deposit date:2007-07-27
Release date:2007-08-14
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries
J.Mol.Biol., 373, 2007
4GLN
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BU of 4gln by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n
Descriptor: D-RFX001, Vascular endothelial growth factor A
Authors:Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQX
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CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)
Descriptor: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
Authors:Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GLS
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BU of 4gls by Molmil
Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21
Descriptor: D- RFX001, D- Vascular endothelial growth factor-A, DI(HYDROXYETHYL)ETHER, ...
Authors:Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQU
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BU of 4hqu by Molmil
Crystal structure of human PDGF-BB in complex with a modified nucleotide aptamer (SOMAmer SL5)
Descriptor: MAGNESIUM ION, Platelet-derived growth factor subunit B, SODIUM ION, ...
Authors:Davies, D.R, Edwards, T.E, Janjic, N, Gelinas, A.D, Zhang, C, Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
3S1K
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BU of 3s1k by Molmil
The Development of Peptide-based Tools for the Analysis of Angiogenesis
Descriptor: Vascular endothelial growth factor A, Z-domain
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2011-05-15
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011
1BJ1
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BU of 1bj1 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
Descriptor: Fab fragment, heavy chain, light chain, ...
Authors:Muller, Y.A, Christinger, H.W, De Vos, A.M.
Deposit date:1998-06-30
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
1CZ8
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BU of 1cz8 by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Descriptor: HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ...
Authors:Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B.
Deposit date:1999-09-01
Release date:2000-03-20
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
4QCI
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BU of 4qci by Molmil
PDGF-B blocking antibody bound to PDGF-BB
Descriptor: Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain
Authors:Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G.
Deposit date:2014-05-12
Release date:2015-03-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
4WPB
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BU of 4wpb by Molmil
Vascular endothelial growth factor in complex with alpha/beta-VEGF-1
Descriptor: Vascular endothelial growth factor A, alpha/beta-VEGF-1
Authors:Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T.
Deposit date:2014-10-17
Release date:2015-04-15
Last modified:2024-07-10
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZFF
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BU of 4zff by Molmil
Dual-acting Fab 5A12 in complex with VEGF
Descriptor: Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ...
Authors:Harris, S.F, Wu, P.
Deposit date:2015-04-21
Release date:2015-07-01
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration.
J.Biol.Chem., 290, 2015
1FZV
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BU of 1fzv by Molmil
THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, PLACENTA GROWTH FACTOR
Authors:Iyer, S, Leonidas, D.D, Swaminathan, G.J, Maglione, D, Battisti, M, Tucci, M, Persico, M.G, Acharya, K.R.
Deposit date:2000-10-04
Release date:2001-05-09
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
J.Biol.Chem., 276, 2001
3S1B
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BU of 3s1b by Molmil
The Development of Peptide-based Tools for the Analysis of Angiogenesis
Descriptor: Vascular endothelial growth factor A, mini-Z
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2011-05-14
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011
1PDG
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BU of 1pdg by Molmil
CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB
Descriptor: PLATELET-DERIVED GROWTH FACTOR BB
Authors:Oefner, C, Darcy, A.D, Winkler, F.K, Eggimann, B, Hosnag, M.
Deposit date:1992-07-14
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human platelet-derived growth factor BB.
EMBO J., 11, 1992
6T9D
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BU of 6t9d by Molmil
Crystal structure of a bispecific DutaFab in complex with human VEGF121
Descriptor: VP mat DutaFab VH chain, VP mat DutaFab VL chain, Vascular endothelial growth factor A
Authors:Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H.
Deposit date:2019-10-28
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.
Nat Commun, 12, 2021
6T9E
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BU of 6t9e by Molmil
Crystal structure of a bispecific DutaFab in complex with human PDGF
Descriptor: DutaFab mat VH chain, DutaFab mat VL chain, Platelet-derived growth factor subunit B
Authors:Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H.
Deposit date:2019-10-28
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.
Nat Commun, 12, 2021
6V7K
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BU of 6v7k by Molmil
Crystal Structure of Vascular Endothelial Growth Factor (VEGF8-109) with one copy of HH4, an alpha/beta-Peptide with Irregular Secondary Structure
Descriptor: Vascular endothelial growth factor A, alpha/beta-Peptide HH4
Authors:Thomas, N.C, Forest, K.T, Gellman, S.H.
Deposit date:2019-12-08
Release date:2020-12-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:High-Resolution Structure for a Complex Between One Copy of a Non-Helical Foldamer and VEGF
to be published
5FV2
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BU of 5fv2 by Molmil
Crystal structure of hVEGF in complex with VH domain antibody
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR, VH DOMAIN ANTIBODY
Authors:Chung, C, Batuwangala, T.
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
3P9W
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BU of 3p9w by Molmil
Crystal structure of an engineered human autonomous VH Domain in complex with VEGF
Descriptor: Vascular endothelial growth factor A, human VEGF
Authors:Ma, X, Wiesmann, C.
Deposit date:2010-10-18
Release date:2012-04-18
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.
J.Mol.Biol., 425, 2013
2FJH
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BU of 2fjh by Molmil
Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
Descriptor: Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A
Authors:Wiesmann, C.
Deposit date:2006-01-02
Release date:2006-02-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2C7W
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BU of 2c7w by Molmil
Crystal Structure of human vascular endothelial growth factor-B: Identification of amino acids important for angiogeninc activity
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
Authors:Iyer, S, Scotney, P.D, Nash, A.D, Acharya, K.R.
Deposit date:2005-11-29
Release date:2007-01-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
J.Mol.Biol., 359, 2006

 

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數據於2024-09-25公開中

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