2FJH
Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF
Summary for 2FJH
Entry DOI | 10.2210/pdb2fjh/pdb |
Related | 1FLT 2FJF 2FJG |
Descriptor | Vascular endothelial growth factor A, Fab fragment light chain, Fab fragment heavy chain (3 entities in total) |
Functional Keywords | vegf, fab, protein fab complex, cystine knot, hormone-growth factor-immune system complex, hormone/growth factor/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: Q96NW5 |
Total number of polymer chains | 6 |
Total formula weight | 118801.16 |
Authors | Wiesmann, C. (deposition date: 2006-01-02, release date: 2006-02-07, Last modification date: 2023-08-30) |
Primary citation | Fuh, G.,Wu, P.,Liang, W.C.,Ultsch, M.,Lee, C.V.,Moffat, B.,Wiesmann, C. Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab. J.Biol.Chem., 281:6625-6631, 2006 Cited by PubMed: 16373345DOI: 10.1074/jbc.M507783200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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