2FJF

Structure of the G6 Fab, a phage derived VEGF binding Fab

Summary for 2FJF

• Entry DOI: 10.2210/pdb2fjf/pdb
• Related: 1FLT 2fjg 2fjh
• Descriptor: Light Chain of a VEGF binding Antibody, Heavy Chain of a VEGF binding Antibody (3 entities in total)
• Functional Keywords: antibody, fab, dodecamer, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 24
• Total formula weight: 569014.62

Authors

Wiesmann, C. (deposition date: 2006-01-02, release date: 2006-02-07, Last modification date: 2011-07-13)

• Primary citation: Fuh, G.,Wu, P.,Liang, W.C.,Ultsch, M.,Lee, C.V.,Moffat, B.,Wiesmann, C.; Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.; J.Biol.Chem., 281:6625-6631, 2006; PubMed: 16373345; DOI: 10.1074/jbc.M507783200

Experimental method

X-RAY DIFFRACTION (2.65 Å)