2FJH

Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF

Summary for 2FJH

• Entry DOI: 10.2210/pdb2fjh/pdb
• Related: 1FLT 2FJF 2FJG
• Descriptor: Vascular endothelial growth factor A, Fab fragment light chain, Fab fragment heavy chain (3 entities in total)
• Functional Keywords: vegf, fab, protein fab complex, cystine knot, hormone-growth factor-immune system complex, hormone/growth factor/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: Q96NW5
• Total number of polymer chains: 6
• Total formula weight: 118801.16

Authors

Wiesmann, C. (deposition date: 2006-01-02, release date: 2006-02-07, Last modification date: 2023-08-30)

• Primary citation: Fuh, G.,Wu, P.,Liang, W.C.,Ultsch, M.,Lee, C.V.,Moffat, B.,Wiesmann, C.; Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.; J.Biol.Chem., 281:6625-6631, 2006; PubMed: 16373345; DOI: 10.1074/jbc.M507783200

Experimental method

X-RAY DIFFRACTION (3.1 Å)