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2FJG

Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF

Summary for 2FJG
Entry DOI10.2210/pdb2fjg/pdb
Related1FLT 2FJF 2FJH
DescriptorVascular endothelial growth factor A, Fab light chain, Fab heavy chain, ... (4 entities in total)
Functional Keywordsprotein fab complex, fab, vegf, cystine knot, hormone-growth factor-immune system complex, hormone/growth factor/immune system
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: Q96NW5
Total number of polymer chains6
Total formula weight119405.57
Authors
Wiesmann, C. (deposition date: 2006-01-02, release date: 2006-02-07, Last modification date: 2023-08-30)
Primary citationFuh, G.,Wu, P.,Liang, W.C.,Ultsch, M.,Lee, C.V.,Moffat, B.,Wiesmann, C.
Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281:6625-6631, 2006
Cited by
PubMed: 16373345
DOI: 10.1074/jbc.M507783200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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