3BDY

Dual specific bH1 Fab in complex with VEGF

Summary for 3BDY

• Entry DOI: 10.2210/pdb3bdy/pdb
• Related: 3BE1
• Descriptor: Fab Fragment -Heavy Chain, Fab Fragment -Light Chain, Vascular endothelial growth factor A, ... (5 entities in total)
• Functional Keywords: fab complex, angiogenesis, developmental protein, differentiation, glycoprotein, growth factor, heparin-binding, mitogen, secreted, hormone
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted : P15692
• Total number of polymer chains: 3
• Total formula weight: 60554.81

Authors

Bostrom, J.M.,Wiesmann, C.,Appleton, B.A. (deposition date: 2007-11-15, release date: 2008-11-18, Last modification date: 2023-08-30)

• Primary citation: Bostrom, J.,Yu, S.F.,Kan, D.,Appleton, B.A.,Lee, C.V.,Billeci, K.,Man, W.,Peale, F.,Ross, S.,Wiesmann, C.,Fuh, G.; Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site; Science, 323:1610-1614, 2009; PubMed: 19299620; DOI: 10.1126/science.1165480

Experimental method

X-RAY DIFFRACTION (2.6 Å)