3BE1
Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2
Summary for 3BE1
Entry DOI | 10.2210/pdb3be1/pdb |
Related | 2jp9 2jpa 3BDY |
Descriptor | Receptor tyrosine-protein kinase erbB-2, Fab Fragment-Heavy Chain, Fab Fragment-Light Chain, ... (5 entities in total) |
Functional Keywords | fab complex, atp-binding, glycoprotein, kinase, membrane, nucleotide-binding, phosphorylation, receptor, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 117945.78 |
Authors | Bostrom, J.M.,Wiesmann, C.,Appleton, B.A. (deposition date: 2007-11-15, release date: 2008-11-18, Last modification date: 2023-08-30) |
Primary citation | Bostrom, J.,Yu, S.F.,Kan, D.,Appleton, B.A.,Lee, C.V.,Billeci, K.,Man, W.,Peale, F.,Ross, S.,Wiesmann, C.,Fuh, G. Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site Science, 323:1610-1614, 2009 Cited by PubMed: 19299620DOI: 10.1126/science.1165480 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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