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3BE1

Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2

Summary for 3BE1
Entry DOI10.2210/pdb3be1/pdb
Related2jp9 2jpa 3BDY
DescriptorReceptor tyrosine-protein kinase erbB-2, Fab Fragment-Heavy Chain, Fab Fragment-Light Chain, ... (5 entities in total)
Functional Keywordsfab complex, atp-binding, glycoprotein, kinase, membrane, nucleotide-binding, phosphorylation, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains3
Total formula weight117945.78
Authors
Bostrom, J.M.,Wiesmann, C.,Appleton, B.A. (deposition date: 2007-11-15, release date: 2008-11-18, Last modification date: 2023-08-30)
Primary citationBostrom, J.,Yu, S.F.,Kan, D.,Appleton, B.A.,Lee, C.V.,Billeci, K.,Man, W.,Peale, F.,Ross, S.,Wiesmann, C.,Fuh, G.
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323:1610-1614, 2009
Cited by
PubMed: 19299620
DOI: 10.1126/science.1165480
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

217705

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