1CZ8
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Summary for 1CZ8
Entry DOI | 10.2210/pdb1cz8/pdb |
Related | 1BJ1 1FLT 1VPF 1VPP |
Descriptor | Vascular endothelial growth factor A, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, HEAVY CHAIN OF NEUTRALIZING ANTIBODY, ... (5 entities in total) |
Functional Keywords | complex (antibody-antigen), cystine knot, fab fragment, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted : P15692 |
Total number of polymer chains | 6 |
Total formula weight | 119059.19 |
Authors | Chen, Y.,Wiesmann, C.,Fuh, G.,Li, B.,Christinger, H.W.,McKay, P.,de Vos, A.M.,Lowman, H.B. (deposition date: 1999-09-01, release date: 2000-03-20, Last modification date: 2017-04-05) |
Primary citation | Chen, Y.,Wiesmann, C.,Fuh, G.,Li, B.,Christinger, H.W.,McKay, P.,de Vos, A.M.,Lowman, H.B. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J.Mol.Biol., 293:865-881, 1999 Cited by PubMed: 10543973DOI: 10.1006/jmbi.1999.3192 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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