1BJ1

VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY

Summary for 1BJ1

• Entry DOI: 10.2210/pdb1bj1/pdb
• Descriptor: Fab fragment, light chain, Fab fragment, heavy chain, Vascular endothelial growth factor A, ... (5 entities in total)
• Functional Keywords: complex (antibody-antigen), angiogenic factor, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 120814.91

Authors

Muller, Y.A.,Christinger, H.W.,De Vos, A.M. (deposition date: 1998-06-30, release date: 1999-01-13, Last modification date: 2024-11-13)

Primary citation

Muller, Y.A.,Chen, Y.,Christinger, H.W.,Li, B.,Cunningham, B.C.,Lowman, H.B.,de Vos, A.M.
VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6:1153-1167, 1998

PubMed Abstract: Vascular endothelial growth factor (VEGF) is a highly specific angiogenic growth factor; anti-angiogenic treatment through inhibition of receptor activation by VEGF might have important therapeutic applications in diseases such as diabetic retinopathy and cancer. A neutralizing anti-VEGF antibody shown to suppress tumor growth in an in vivo murine model has been used as the basis for production of a humanized version.

PubMed: 9753694
DOI: 10.1016/S0969-2126(98)00116-6

Experimental method

X-RAY DIFFRACTION (2.4 Å)