1PDG

CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB

Summary for 1PDG

• Entry DOI: 10.2210/pdb1pdg/pdb
• Descriptor: PLATELET-DERIVED GROWTH FACTOR BB (1 entity in total)
• Functional Keywords: growth factor
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P01127
• Total number of polymer chains: 3
• Total formula weight: 36940.50

Authors

Oefner, C.,Darcy, A.D.,Winkler, F.K.,Eggimann, B.,Hosnag, M. (deposition date: 1992-07-14, release date: 1994-01-31, Last modification date: 2024-11-13)

Primary citation

Oefner, C.,D'Arcy, A.,Winkler, F.K.,Eggimann, B.,Hosang, M.
Crystal structure of human platelet-derived growth factor BB.
EMBO J., 11:3921-3926, 1992

PubMed Abstract: The crystal structure of the homodimeric BB isoform of human recombinant platelet-derived growth factor (PDGF-BB) has been determined by X-ray analysis to 3.0 A resolution. The polypeptide chain is folded into two highly twisted antiparallel pairs of beta-strands and contains an unusual knotted arrangement of three intramolecular disulfide bonds. Dimerization leads to the clustering of three surface loops at each end of the elongated dimer, which most probably form the receptor recognition sites.

PubMed: 1396586

Experimental method

X-RAY DIFFRACTION (3 Å)