Author results

5TWO
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A NOVEL SELECTIVELY PPAR GAMMA-MODULATING LIGAND VSP-51
Descriptor:Peroxisome proliferator-activated receptor gamma, PRO-SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO, N-benzyl-1-[(4-chloro-3-fluorophenyl)methyl]-1H-indole-5-carboxamide
Authors:Yi, W., Shi, J., Zhao, G., Zhou, X.E., Suino-Powell, K., Melcher, K., Xu, H.E.
Deposit date:2016-11-14
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.927 Å)
Cite:Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro.
Sci Rep, 7, 2017
3GYT
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NUCLEAR RECEPTOR DAF-12 FROM PARASITIC NEMATODE STRONGYLOIDES STERCORALIS IN COMPLEX WITH ITS PHYSIOLOGICAL LIGAND DAFACHRONIC ACID DELTA 4
Descriptor:Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily, SRC1, (14beta,17alpha,25R)-3-oxocholest-4-en-26-oic acid
Authors:Zhou, X.E., Wang, Z., Suino-Powell, K., Motola, D.L., Conneely, A., Ogata, C., Sharma, K.K., Auchus, R.J., Kliewer, S.A., Xu, H.E., Mangelsdorf, D.J.
Deposit date:2009-04-05
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proc.Natl.Acad.Sci.USA, 106, 2009
3GYU
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NUCLEAR RECEPTOR DAF-12 FROM PARASITIC NEMATODE STRONGYLOIDES STERCORALIS IN COMPLEX WITH ITS PHYSIOLOGICAL LIGAND DAFACHRONIC ACID DELTA 7
Descriptor:Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily, SRC1, (5beta,14beta,17alpha,25R)-3-oxocholest-7-en-26-oic acid
Authors:Zhou, X.E., Wang, Z., Suino-Powell, K., Motola, D.L., Conneely, A., Ogata, C., Sharma, K.K., Auchus, R.J., Kliewer, S.A., Xu, H.E., Mangelsdorf, D.J.
Deposit date:2009-04-05
Release date:2009-07-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Proc.Natl.Acad.Sci.USA, 106, 2009
3BQD
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DOUBLING THE SIZE OF THE GLUCOCORTICOID RECEPTOR LIGAND BINDING POCKET BY DEACYLCORTIVAZOL
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 1, 1-[(1R,2R,3aS,3bS,10aR,10bS,11S,12aS)-1,11-dihydroxy-2,5,10a,12a-tetramethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]-2-hydroxyethanone
Authors:Xu, H.E.
Deposit date:2007-12-20
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.
Mol.Cell.Biol., 28, 2008
4P6W
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CRYSTAL STRUCTURE OF MOMETASONE FUROATE-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, MOMETASONE FUROATE
Authors:He, Y., Zhou, X.E., Tolbert, W.D., Powell, K., Melcher, K., Xu, H.E.
Deposit date:2014-03-25
Release date:2014-04-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Structures and mechanism for the design of highly potent glucocorticoids.
Cell Res., 24, 2014
4P6X
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CRYSTAL STRUCTURE OF CORTISOL-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Authors:He, Y., Zhou, X.E., Tolbert, W.D., Powell, K., Melcher, K., Xu, H.E.
Deposit date:2014-03-25
Release date:2014-04-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures and mechanism for the design of highly potent glucocorticoids.
Cell Res., 24, 2014
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
Descriptor:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
Deposit date:2017-10-21
Release date:2018-08-22
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
3CJW
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CRYSTAL STRUCTURE OF THE HUMAN COUP-TFII LIGAND BINDING DOMAIN
Descriptor:COUP transcription factor 2
Authors:Kruse, S.W., Reynolds, R., Vonrhein, C., Xu, H.E.
Deposit date:2008-03-14
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid-Activated Receptor.
Plos Biol., 6, 2008
3CS8
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STRUCTURAL AND BIOCHEMICAL BASIS FOR THE BINDING SELECTIVITY OF PPARG TO PGC-1A
Descriptor:Peroxisome proliferator-activated receptor gamma, PGC-1alfa peptide, SULFATE ION, ...
Authors:Li, Y., Martynowski, D.
Deposit date:2008-04-09
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha.
J.Biol.Chem., 283, 2008
3CWD
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MOLECULAR RECOGNITION OF NITRO-FATTY ACIDS BY PPAR GAMMA
Descriptor:Peroxisome proliferator-activated receptor gamma, SRC1-2 PEPTIDE, (9E,12Z)-10-nitrooctadeca-9,12-dienoic acid, ...
Authors:Martynowski, D., Li, Y.
Deposit date:2008-04-21
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular recognition of nitrated fatty acids by PPAR gamma.
Nat.Struct.Mol.Biol., 15, 2008
3EHS
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR TYPE 1 (CRFR1)
Descriptor:fusion protein of CRFR1 extracellular domain and MBP, MALTOSE
Authors:Pioszak, A.A., Xu, H.E.
Deposit date:2008-09-14
Release date:2008-09-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1.
J.Biol.Chem., 283, 2008
3EHT
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR TYPE 1 (CRFR1) IN COMPLEX WITH CRF
Descriptor:FUSION PROTEIN OF CRFR1 EXTRACELLULAR DOMAIN AND MBP, Corticoliberin, MALTOSE
Authors:Pioszak, A.A., Xu, H.E.
Deposit date:2008-09-14
Release date:2008-09-30
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1.
J.Biol.Chem., 283, 2008
3EHU
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CORTICOTROPIN RELEASING FACTOR RECEPTOR TYPE 1 (CRFR1) IN COMPLEX WITH CRF
Descriptor:FUSION PROTEIN OF CRFR1 EXTRACELLULAR DOMAIN AND MBP, Corticoliberin, CALCIUM ION, ...
Authors:Pioszak, A.A., Xu, H.E.
Deposit date:2008-09-14
Release date:2008-09-30
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1.
J.Biol.Chem., 283, 2008