7JHG
Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody
Summary for 7JHG
Entry DOI | 10.2210/pdb7jhg/pdb |
Related | 7JHH |
EMDB information | 22336 22337 |
Related PRD ID | PRD_900001 |
Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-1, ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... (12 entities in total) |
Functional Keywords | ampk, atp, fully inactive, kd-displaced, transferase-immune system complex, transferase/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 7 |
Total formula weight | 222183.50 |
Authors | Yan, Y.,Murkherjee, S.,Zhou, X.E.,Xu, T.H.,Xu, H.E.,Kossiakoff, A.A.,Melcher, K. (deposition date: 2020-07-20, release date: 2021-07-21, Last modification date: 2021-12-15) |
Primary citation | Yan, Y.,Mukherjee, S.,Harikumar, K.G.,Strutzenberg, T.S.,Zhou, X.E.,Suino-Powell, K.,Xu, T.H.,Sheldon, R.D.,Lamp, J.,Brunzelle, J.S.,Radziwon, K.,Ellis, A.,Novick, S.J.,Vega, I.E.,Jones, R.G.,Miller, L.J.,Xu, H.E.,Griffin, P.R.,Kossiakoff, A.A.,Melcher, K. Structure of an AMPK complex in an inactive, ATP-bound state. Science, 373:413-419, 2021 Cited by PubMed: 34437114DOI: 10.1126/science.abe7565 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.47 Å) |
Structure validation
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