7JHG

Cryo-EM structure of ATP-bound fully inactive AMPK in complex with Dorsomorphin (Compound C) and Fab-nanobody

Summary for 7JHG

• Entry DOI: 10.2210/pdb7jhg/pdb
• Related: 7JHH
• EMDB information: 22336 22337
• Related PRD ID: PRD_900001
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... (12 entities in total)
• Functional Keywords: ampk, atp, fully inactive, kd-displaced, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 222183.50

Authors

Yan, Y.,Murkherjee, S.,Zhou, X.E.,Xu, T.H.,Xu, H.E.,Kossiakoff, A.A.,Melcher, K. (deposition date: 2020-07-20, release date: 2021-07-21, Last modification date: 2021-12-15)

• Primary citation: Yan, Y.,Mukherjee, S.,Harikumar, K.G.,Strutzenberg, T.S.,Zhou, X.E.,Suino-Powell, K.,Xu, T.H.,Sheldon, R.D.,Lamp, J.,Brunzelle, J.S.,Radziwon, K.,Ellis, A.,Novick, S.J.,Vega, I.E.,Jones, R.G.,Miller, L.J.,Xu, H.E.,Griffin, P.R.,Kossiakoff, A.A.,Melcher, K.; Structure of an AMPK complex in an inactive, ATP-bound state.; Science, 373:413-419, 2021; PubMed: 34437114; DOI: 10.1126/science.abe7565

Experimental method

ELECTRON MICROSCOPY (3.47 Å)