4P6X

Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain

Summary for 4P6X

Related4P6W
DescriptorGlucocorticoid receptor, Nuclear receptor coactivator 2, (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, ... (4 entities in total)
Functional Keywordscortisol, glucocorticoid receptor, potency, hormone-hormone receptor complex, hormone receptor-hormone activator complex, hormone receptor/hormone activator
Biological sourceHomo sapiens (Human)
Cellular locationIsoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus  P04150
Nucleus Q15596
Total number of polymer chains12
Total molecular weight189845.38
Authors
He, Y.,Zhou, X.E.,Tolbert, W.D.,Powell, K.,Melcher, K.,Xu, H.E. (deposition date: 2014-03-25, release date: 2014-04-16, Last modification date: 2017-09-27)
Primary citation
He, Y.,Yi, W.,Suino-Powell, K.,Zhou, X.E.,Tolbert, W.D.,Tang, X.,Yang, J.,Yang, H.,Shi, J.,Hou, L.,Jiang, H.,Melcher, K.,Xu, H.E.
Structures and mechanism for the design of highly potent glucocorticoids.
Cell Res., 24:713-726, 2014
PubMed: 24763108 (PDB entries with the same primary citation)
DOI: 10.1038/cr.2014.52
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.275151.8%5.5%8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4p6x
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Molmil generated image of 4p6x
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Molmil generated image of 4p6x
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More Biological unit images

Molmil generated image of 4p6x
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Molmil generated image of 4p6x
rotated about x axis by 90°
Molmil generated image of 4p6x
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4p6x.pdb2.gz [50.62 KB])
Coordinate files for Biological unit (4p6x.pdb4.gz [50.33 KB])
Coordinate files for Biological unit (4p6x.pdb6.gz [50.83 KB])
Coordinate files for Biological unit (4p6x.pdb5.gz [50.33 KB])
Coordinate files for Biological unit (4p6x.pdb1.gz [49.23 KB])
Coordinate files for Biological unit (4p6x.pdb3.gz [49.89 KB])