4P6X
Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Glucocorticoid receptor | polymer | 255 | 29569.5 | 6 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Nuclear receptor coactivator 2 | polymer | 14 | 1708.9 | 6 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | M, N, O, P, Q... (A, C, E, G, I...) | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione | non-polymer | 362.5 | 6 | Chemie (HCY) PubChem (16757875) PubChem (16760505) PubChem (17749280) PubChem (18635646) PubChem (3640) PubChem (5754) PubChem (176519891) PubChem (22841298) PubChem (108888) PubChem (23766831) PubChem (16401107) PubChem (24867549) PubChem (40469544) PubChem (40469545) PubChem (40488894) PubChem (40543465) PubChem (40543468) PubChem (40543471) PubChem (40543474) PubChem (40776161) PubChem (44656583) PubChem (1768391) PubChem (1768392) PubChem (1768390) PubChem (46885418) PubChem (46907807) PubChem (657311) PubChem (50987195) PubChem (50987424) PubChem (969496) PubChem (56614803) PubChem (56635598) PubChem (1350204) PubChem (57232608) PubChem (3246033) PubChem (57536781) PubChem (59582250) PubChem (60111544) PubChem (5320346) PubChem (6603869) PubChem (6713680) PubChem (229860) PubChem (7048969) PubChem (7067813) PubChem (89693181) PubChem (8015711) PubChem (11279933) PubChem (1403277) PubChem (11869394) PubChem (11869395) PubChem (11869396) PubChem (12304007) PubChem (12304008) PubChem (12304009) PubChem (12304012) PubChem (12304023) PubChem (6336184) PubChem (101739542) PubChem (6981543) PubChem (7059531) PubChem (122664736) PubChem (12304018) PubChem (124351407) PubChem (124404247) PubChem (124514954) PubChem (124746079) PubChem (125037485) PubChem (129009993) PubChem (129010215) PubChem (132012242) PubChem (154825154) PubChem (159059490) PubChem (162927257) PubChem (162927258) PubChem (165944364) PubChem (166480825) PubChem (169428820) PubChem (172400002) PubChem (172873892) PubChem (173540535) | |||
| 4 | AA, BA, CA, DA, S... (I, J, K, L, A...) | water | water | 18.0 | 618 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K: 523 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ala 602 | Phe 602 | engineered mutation |
| Tyr 622 | Cys 622 | engineered mutation |
| Val 668 | Thr 668 | engineered mutation |
| Thr 674 | Ser 674 | engineered mutation |
| Ile 675 | Val 675 | engineered mutation |
| Ala 684 | Glu 684 | engineered mutation |
| Ala 688 | Glu 688 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 187670.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2174.8 | |
| All* | Total formula weight | 189845.4 |
