4P6X
Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Glucocorticoid receptor | polymer | 255 | 29569.5 | 6 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Nuclear receptor coactivator 2 | polymer | 14 | 1708.9 | 6 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | M, N, O, P, Q... (A, C, E, G, I...) | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione | non-polymer | 362.5 | 6 | Chemie (HCY) | |||
| 4 | AA, BA, CA, DA, S... (I, J, K, L, A...) | water | water | 18.0 | 618 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K: 523 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ala 602 | Phe 602 | engineered mutation |
| Tyr 622 | Cys 622 | engineered mutation |
| Val 668 | Thr 668 | engineered mutation |
| Thr 674 | Ser 674 | engineered mutation |
| Ile 675 | Val 675 | engineered mutation |
| Ala 684 | Glu 684 | engineered mutation |
| Ala 688 | Glu 688 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 187670.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2174.8 | |
| All* | Total formula weight | 189845.4 |
