4P6X
Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue HCY A 900 |
| Chain | Residue |
| A | LEU563 |
| A | THR739 |
| A | ILE747 |
| A | HOH1016 |
| A | ASN564 |
| A | GLN570 |
| A | MET604 |
| A | ARG611 |
| A | PHE623 |
| A | GLN642 |
| A | TYR735 |
| A | CYS736 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue HCY C 900 |
| Chain | Residue |
| C | LEU563 |
| C | ASN564 |
| C | GLN570 |
| C | MET604 |
| C | ARG611 |
| C | PHE623 |
| C | GLN642 |
| C | TYR735 |
| C | CYS736 |
| C | THR739 |
| C | ILE747 |
| C | HOH1010 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue HCY E 900 |
| Chain | Residue |
| E | LEU563 |
| E | ASN564 |
| E | GLN570 |
| E | ARG611 |
| E | PHE623 |
| E | GLN642 |
| E | TYR735 |
| E | CYS736 |
| E | THR739 |
| E | ILE747 |
| E | HOH1059 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue HCY G 900 |
| Chain | Residue |
| G | LEU563 |
| G | ASN564 |
| G | GLN570 |
| G | MET604 |
| G | ARG611 |
| G | PHE623 |
| G | GLN642 |
| G | TYR735 |
| G | CYS736 |
| G | THR739 |
| G | ILE747 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue HCY I 900 |
| Chain | Residue |
| I | LEU563 |
| I | ASN564 |
| I | GLN570 |
| I | MET604 |
| I | ARG611 |
| I | PHE623 |
| I | GLN642 |
| I | TYR735 |
| I | CYS736 |
| I | THR739 |
| I | ILE747 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue HCY K 900 |
| Chain | Residue |
| K | LEU563 |
| K | ASN564 |
| K | GLN570 |
| K | MET604 |
| K | ARG611 |
| K | PHE623 |
| K | GLN642 |
| K | TYR735 |
| K | CYS736 |
| K | THR739 |
| K | ILE747 |
| K | HOH1029 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 990 |
| Details | Region: {"description":"Interaction with CRY1","evidences":[{"source":"PubMed","id":"22170608","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"12144530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1170 |
| Details | Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Motif: {"description":"LXXLL motif 3"} |
| Chain | Residue | Details |
