3BQD

Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

Summary for 3BQD

• Entry DOI: 10.2210/pdb3bqd/pdb
• Related: 1M2Z
• Descriptor: Glucocorticoid receptor, Nuclear receptor coactivator 1, 1-[(1R,2R,3aS,3bS,10aR,10bS,11S,12aS)-1,11-dihydroxy-2,5,10a,12a-tetramethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]-2-hydroxyethanone, ... (4 entities in total)
• Functional Keywords: glucocorticoid receptor, deacylcortivazol, src1, nuclear receptor coactivator 1 isoform 1, dimer interface, hormone binding pocket, charge clamp, coactivator, alternative initiation, alternative splicing, chromatin regulator, cytoplasm, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, polymorphism, pseudohermaphroditism, steroid-binding, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, proto-oncogene, transferase, protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm. Isoform Beta: Nucleus: P04150; Nucleus (By similarity): Q15788
• Total number of polymer chains: 2
• Total formula weight: 31576.74

Authors

Xu, H.E. (deposition date: 2007-12-20, release date: 2008-01-15, Last modification date: 2023-08-30)

• Primary citation: Suino-Powell, K.,Xu, Y.,Zhang, C.,Tao, Y.G.,Tolbert, W.D.,Simons, S.S.,Xu, H.E.; Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol.; Mol.Cell.Biol., 28:1915-1923, 2008; PubMed: 18160712; DOI: 10.1128/MCB.01541-07

Experimental method

X-RAY DIFFRACTION (2.5 Å)