3BQD
Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid receptor | polymer | 255 | 29587.4 | 1 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B (B) | Nuclear receptor coactivator 1 | polymer | 13 | 1500.7 | 1 | UniProt (Q15788) | NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52 | |
| 3 | C (A) | 1-[(1R,2R,3aS,3bS,10aR,10bS,11S,12aS)-1,11-dihydroxy-2,5,10a,12a-tetramethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]-2-hydroxyethanone | non-polymer | 488.6 | 1 | Chemie (DAY) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 525 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 523 | - | expression tag |
| Ser 524 | - | expression tag |
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31088.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 488.6 | |
| All* | Total formula weight | 31576.7 |
