3EHT

Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF

Summary for 3EHT

Entry DOI	10.2210/pdb3eht/pdb
Related	3EHS 3EHU
Related PRD ID	PRD_900001
Descriptor	FUSION PROTEIN OF CRFR1 EXTRACELLULAR DOMAIN AND MBP, Corticoliberin, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
Functional Keywords	g protein-coupled receptor, corticotropin releasing factor, scr fold, mbp fusion, extracellular domain, sugar transport, transport, cell membrane, glycoprotein, membrane, phosphoprotein, receptor, transducer, transmembrane, amidation, cleavage on pair of basic residues, hormone, secreted, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	2
Total formula weight	54624.46
Authors	Pioszak, A.A.,Xu, H.E. (deposition date: 2008-09-14, release date: 2008-09-30, Last modification date: 2023-08-30)
Primary citation	Pioszak, A.A.,Parker, N.R.,Suino-Powell, K.,Xu, H.E. Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1. J.Biol.Chem., 283:32900-32912, 2008 Cited by PubMed: 18801728 DOI: 10.1074/jbc.M805749200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation