3EHT
Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | FUSION PROTEIN OF CRFR1 EXTRACELLULAR DOMAIN AND MBP | polymer | 476 | 52529.1 | 1 | UniProt (P0AEX9) UniProt (P34998) Pfam (PF01547) Pfam (PF02793) | Escherichia coli | MMBP, Maltodextrin-binding protein, CRF-R, CRF1, Corticotropin-releasing hormone receptor 1, CRH-R 1 |
| 2 | B (B) | Corticoliberin | polymer | 16 | 1753.1 | 1 | UniProt (P06850) Pfam (PF00473) | synthetic construct | Corticotropin-releasing hormone, Corticotropin-releasing factor, CRF |
| 3 | C (C) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose |
Sequence modifications
A: -349 - 17 (UniProt: P0AEX9)
A: 24 - 119 (UniProt: P34998)
| PDB | External Database | Details |
|---|---|---|
| Met -350 | - | initiating methionine |
| Glu -257 | Phe 118 | engineered mutation |
| Asn 18 | - | linker |
| Ala 19 | - | linker |
| Ala 20 | - | linker |
| Ala 21 | - | linker |
| Glu 22 | - | linker |
| Phe 23 | - | linker |
| His 120 | - | expression tag |
| His 121 | - | expression tag |
| His 122 | - | expression tag |
| His 123 | - | expression tag |
| His 124 | - | expression tag |
| His 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54282.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| All* | Total formula weight | 54624.5 |
