Structural and Biochemical Basis for the Binding Selectivity of PPARg to PGC-1a

Summary for 3CS8

DescriptorPeroxisome proliferator-activated receptor gamma, PGC-1alfa peptide, SULFATE ION, ... (5 entities in total)
Functional Keywordscoactivator, nuclear receptor, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, transcription, transcription regulation, zinc, zinc-finger, rna-binding, nuclear protein
Biological sourceHomo sapiens
Cellular locationNucleus P37231 Q9UBK2
Total number of polymer chains2
Total molecular weight33296.64
Li, Y.,Martynowski, D. (deposition date: 2008-04-09, release date: 2008-06-03, Last modification date: 2011-07-13)
Primary citation
Li, Y.,Kovach, A.,Suino-Powell, K.,Martynowski, D.,Xu, H.E.
Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor gamma to PGC-1alpha.
J.Biol.Chem., 283:19132-19139, 2008
PubMed: 18469005 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M802040200
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.282211.8%8.8%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report