3CS8
Structural and Biochemical Basis for the Binding Selectivity of PPARg to PGC-1a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peroxisome proliferator-activated receptor gamma | polymer | 275 | 31289.3 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 2 | B (B) | PGC-1alfa peptide | polymer | 12 | 1265.6 | 1 | UniProt (Q9UBK2) | PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, PGC-1-alpha, Ligand effect modulator 6 | |
| 3 | C, D, E, G (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | F (A) | 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) | non-polymer | 357.4 | 1 | Chemie (BRL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 206 - 476 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Arg 202 | - | expression tag |
| Gly 203 | - | expression tag |
| Gly 204 | - | expression tag |
| Ser 205 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32555.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 741.7 | |
| All* | Total formula weight | 33296.6 |
