3CS8

Structural and Biochemical Basis for the Binding Selectivity of PPARg to PGC-1a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	ARG234
A	MET334
A	ASN335
A	LYS336
A	ASN375

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	ILE445
A	LYS358
A	GLU369
A	PHE370
A	LYS373

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	LYS230
A	ALA231
A	ARG234
A	LEU379
A	ASP380

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1

Chain	Residue
A	GLY204
A	SER205
A	PRO206
B	SER142
B	LYS145
B	LEU149

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BRL A 503

Chain	Residue
A	ILE281
A	CYS285
A	GLN286
A	SER289
A	ILE341
A	MET364
A	LYS367
A	HIS449
A	LEU453
A	LEU469
A	TYR473

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"PubMed","id":"30468856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9744270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PRG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36737649","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---