6MS7
Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selective PPAR-gamma modulator VSP-77
Summary for 6MS7
Entry DOI | 10.2210/pdb6ms7/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, PGC1 LXXLL motif, {[(1S)-1-(4-chlorophenyl)octyl]oxy}acetic acid, ... (4 entities in total) |
Functional Keywords | peroxisome proliferator-activated receptor gamma, lignad binding domain, selective ppar gamma modulator, vsp-77, dna binding protein, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 33030.42 |
Authors | Yi, W.,Jiang, H.,Zhou, X.E.,Shi, J.,Zhao, G.,Zhang, X.,Sun, Y.,Suino-Powell, K.,Li, J.,Li, J.,Melcher, K.,Xu, H.E. (deposition date: 2018-10-16, release date: 2019-10-23, Last modification date: 2024-03-13) |
Primary citation | Jiang, H.,Zhou, X.E.,Shi, J.,Zhou, Z.,Zhao, G.,Zhang, X.,Sun, Y.,Suino-Powell, K.,Ma, L.,Gao, H.,Yu, X.,Li, J.,Li, J.,Melcher, K.,Xu, H.E.,Yi, W. Identification and structural insight of an effective PPAR gamma modulator with improved therapeutic index for anti-diabetic drug discovery. Chem Sci, 11:2260-2268, 2020 Cited by PubMed: 32190280DOI: 10.1039/c9sc05487a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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