6MS7

Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selective PPAR-gamma modulator VSP-77

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue V77 A 600

Chain	Residue
A	ARG288
A	HOH827
A	ALA292
A	TYR327
A	MET329
A	ILE341
A	SER342
A	HIS449
A	V77601
A	HOH712

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site_id	AC2
Number of Residues	16
Details	binding site for residue V77 A 601

Chain	Residue
A	ILE281
A	PHE282
A	CYS285
A	GLN286
A	SER289
A	HIS323
A	PHE360
A	PHE363
A	MET364
A	HIS449
A	LEU453
A	SER464
A	LEU465
A	LEU469
A	TYR473
A	V77600

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O70343

Chain	Residue	Details
B	LYS146
A	HIS323
A	HIS449
A	TYR473

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649

Chain	Residue	Details
A	LYS224

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