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6MS7

Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selective PPAR-gamma modulator VSP-77

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Peroxisome proliferator-activated receptor gammapolymer27431238.31UniProt (P37231)
Pfam (PF00104)
Homo sapiens (Human)PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2B
(B)
PGC1 LXXLL motifpolymer111194.51UniProt (by SIFTS) (Q9UBK2)synthetic construct
3C, D
(A)
{[(1S)-1-(4-chlorophenyl)octyl]oxy}acetic acidnon-polymer298.82Chemie (V77)
4E, F
(A, B)
waterwater18.0272Chemie (HOH)
Sequence modifications
A: 206 - 477 (UniProt: P37231)
PDBExternal DatabaseDetails
Gly 204-expression tag
Ser 205-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight32432.8
Non-Polymers*Number of molecules2
Total formula weight597.6
All*Total formula weight33030.4
*Water molecules are not included.

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PDB entries from 2025-10-15

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