Author results

2OIQ
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CRYSTAL STRUCTURE OF CHICKEN C-SRC KINASE DOMAIN IN COMPLEX WITH THE CANCER DRUG IMATINIB.
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL
Authors:Seeliger, M.A., Nagar, B., Frank, F., Cao, X., Henderson, M.N., Kuriyan, J.
Deposit date:2007-01-11
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty.
Structure, 15, 2007
3G6G
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EQUALLY POTENT INHIBITION OF C-SRC AND ABL BY COMPOUNDS THAT RECOGNIZE INACTIVE KINASE CONFORMATIONS
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, GLYCEROL
Authors:Seeliger, M.A., Ranjitkar, P., Kasap, C., Shan, Y., Shaw, D.E., Shah, N.P., Kuriyan, J., Maly, D.J.
Deposit date:2009-02-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
3G6H
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SRC THR338ILE INHIBITED IN THE DFG-ASP-OUT CONFORMATION
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide
Authors:Seeliger, M.A., Ranjitkar, P., Kasap, C., Shan, Y., Shaw, D.E., Shah, N.P., Kuriyan, J., Maly, D.J.
Deposit date:2009-02-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
3F6X
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C-SRC KINASE DOMAIN IN COMPLEX WITH SMALL MOLECULE INHIBITOR
Descriptor:Proto-oncogene tyrosine-protein kinase Src, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
Authors:Seeliger, M.A., Statsuk, A.V., Maly, D.J., Patrick, P.Z., Kuriyan, J., Shokat, K.M.
Deposit date:2008-11-06
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Tuning a three-component reaction for trapping kinase substrate complexes.
J.Am.Chem.Soc., 130, 2008
3U4W
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SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC4B
Descriptor:Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC4B, GLYCEROL, ...
Authors:Seeliger, M.A., Liu, D.R., Georghiou, G., Kleiner, R.E., Pulkoski-Gross, M.
Deposit date:2011-10-10
Release date:2012-02-22
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
Nat.Chem.Biol., 8, 2012
3U51
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SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC1
Descriptor:Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC1
Authors:Seeliger, M.A., Liu, D.R., Georghiou, G., Kleiner, R.E., Pulkoski-Gross, M.
Deposit date:2011-10-10
Release date:2012-02-22
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.241 Å)
Cite:Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
Nat.Chem.Biol., 8, 2012
6EDS
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STRUCTURE OF CYSTEINE-FREE HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH GLUCAGON AND SUBSTRATE-SELECTIVE MACROCYCLIC INHIBITOR 63
Descriptor:Insulin-degrading enzyme, Glucagon, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol, ...
Authors:Tan, G.A., Seeliger, M.A., Maianti, J.P., Liu, D.R., Welsh, A.J.
Deposit date:2018-08-10
Release date:2019-04-03
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (3.180717 Å)
Cite:Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat.Chem.Biol., 15, 2019
6MQ3
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STRUCTURE OF CYSTEINE-FREE HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH SUBSTRATE-SELECTIVE MACROCYCLE INHIBITOR 63
Descriptor:Insulin-degrading enzyme, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Tan, G.A., Seeliger, M.A., Welsh, A.J., Maianti, J.P., Liu, D.R.
Deposit date:2018-10-09
Release date:2019-04-03
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (3.569147 Å)
Cite:Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat.Chem.Biol., 15, 2019
3DQW
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C-SRC KINASE DOMAIN THR338ILE MUTANT IN COMPLEX WITH ATPGS
Descriptor:Proto-oncogene tyrosine-protein kinase Src, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Azam, M., Seeliger, M.A., Gray, N., Kuriyan, J., Daley, G.Q.
Deposit date:2008-07-09
Release date:2008-09-23
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.017 Å)
Cite:Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Nat.Struct.Mol.Biol., 15, 2008
3DQX
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CHICKEN C-SRC KINASE DOMAIN IN COMPLEX WITH ATPGS
Descriptor:Proto-oncogene tyrosine-protein kinase Src, ADENOSINE MONOPHOSPHATE
Authors:Azam, M., Seeliger, M.A., Gray, N., Kuriyan, J., Daley, G.Q.
Deposit date:2008-07-09
Release date:2008-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Activation of tyrosine kinases by mutation of the gatekeeper threonine.
Nat.Struct.Mol.Biol., 15, 2008
4LTE
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STRUCTURE OF CYSTEINE-FREE HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH MACROCYCLIC INHIBITOR
Descriptor:Insulin-degrading enzyme, Macrocyclic Inhibitor, ZINC ION, ...
Authors:Foda, Z.H., Seeliger, M.A., Saghatelian, A., Liu, D.R.
Deposit date:2013-07-23
Release date:2014-05-21
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (2.705 Å)
Cite:Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
Nature, 511, 2014
3D7T
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STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK
Descriptor:Tyrosine-protein kinase CSK, Proto-oncogene tyrosine-protein kinase Src, STAUROSPORINE
Authors:Levinson, N.M., Seeliger, M.A., Cole, P.A., Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3D7U
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STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK
Descriptor:Tyrosine-protein kinase CSK, Proto-oncogene tyrosine-protein kinase Src
Authors:Levinson, N.M., Seeliger, M.A., Cole, P.A., Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (4.111 Å)
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3GEQ
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STRUCTURAL BASIS FOR THE CHEMICAL RESCUE OF SRC KINASE ACTIVITY
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
Authors:Muratore, K.E., Seeliger, M.A., Wang, Z., Fomina, D., Neiswinger, J., Havranek, J.J., Baker, D., Kuriyan, J., Cole, P.A.
Deposit date:2009-02-25
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry, 48, 2009
3PEU
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S. CEREVISIAE DBP5 L327V C-TERMINAL DOMAIN BOUND TO GLE1 H337R AND IP6
Descriptor:ATP-dependent RNA helicase DBP5, Nucleoporin GLE1, SULFATE ION, ...
Authors:Montpetit, B., Thomsen, N.D., Helmke, K.J., Seeliger, M.A., Berger, J.M., Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEV
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S. CEREVISIAE DBP5 L327V C-TERMINAL DOMAIN BOUND TO GLE1 AND IP6
Descriptor:ATP-dependent RNA helicase DBP5, Nucleoporin GLE1, SULFATE ION, ...
Authors:Montpetit, B., Thomsen, N.D., Helmke, K.J., Seeliger, M.A., Berger, J.M., Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEW
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S. CEREVISIAE DBP5 L327V BOUND TO RNA AND ADP BEF3
Descriptor:ATP-dependent RNA helicase DBP5, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3'), ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Montpetit, B., Thomsen, N.D., Helmke, K.J., Seeliger, M.A., Berger, J.M., Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEY
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S. CEREVISIAE DBP5 BOUND TO RNA AND ADP BEF3
Descriptor:ATP-dependent RNA helicase DBP5, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3'), ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Montpetit, B., Thomsen, N.D., Helmke, K.J., Seeliger, M.A., Berger, J.M., Weis, K.
Deposit date:2010-10-27
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3RRM
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S. CEREVISIAE DBP5 L327V BOUND TO NUP159, GLE1 H337R, IP6 AND ADP
Descriptor:ATP-dependent RNA helicase DBP5, Nucleoporin GLE1, Nucleoporin NUP159, ...
Authors:Montpetit, B., Thomsen, N.D., Helmke, K.J., Seeliger, M.A., Berger, J.M., Weis, K.
Deposit date:2011-04-29
Release date:2011-05-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Nature, 472, 2011
3RRN
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S. CEREVISIAE DBP5 L327V BOUND TO GLE1 H337R AND IP6
Descriptor:ATP-dependent RNA helicase DBP5, Nucleoporin GLE1, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Montpetit, B., Thomsen, N.D., Helmke, K.J., Seeliger, M.A., Berger, J.M., Weis, K.
Deposit date:2011-04-29
Release date:2011-05-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (4.001 Å)
Cite:A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Nature, 472, 2011
4YBJ
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TYPE II DASATINIB ANALOG CRYSTALLIZED WITH C-SRC KINASE
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(3-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1,3-thiazole-5-carboxamide
Authors:Kwarcinski, F.E., Brandvold, K.B., Johnson, T.K., Phadke, S., Meagher, J.L., Seeliger, M.A., Stuckey, J.A., Soellner, M.B.
Deposit date:2015-02-18
Release date:2016-03-02
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.
Acs Chem.Biol., 11, 2016
4YBK
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C-HELIX-OUT DASATINIB ANALOG CRYSTALLIZED WITH C-SRC KINASE
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide
Authors:Kwarcinski, F.E., Brandvold, K.B., Johnson, T.K., Phadke, S., Meagher, J.L., Seeliger, M.A., Stuckey, J.A., Soellner, M.B.
Deposit date:2015-02-18
Release date:2016-03-02
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.
Acs Chem.Biol., 11, 2016
4YC8
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C-HELIX-OUT BINDING OF DASATINIB ANALOG TO C-ABL KINASE
Descriptor:Tyrosine-protein kinase ABL1, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ...
Authors:Kwarcinski, F.E., Brandvold, K.B., Johnson, T.J., Phadke, S., Meagher, J.L., Seeliger, M.A., Stuckey, J.A., Soellner, M.B.
Deposit date:2015-02-19
Release date:2016-03-02
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.
Acs Chem.Biol., 11, 2016
5BMM
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SRC IN COMPLEX WITH DNA-TEMPLATED MACROCYCLIC INHIBITOR MC25B
Descriptor:Proto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC25b
Authors:Georghiou, G., Guja, K.E., Aleem, S., Kleiner, R.E., Liu, D.R., Miller, W.T., Garcia-Diaz, M., Seeliger, M.A.
Deposit date:2015-05-22
Release date:2016-09-21
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.
Cell Chem Biol, 23, 2016
5HGI
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CRYSTAL STRUCTURE OF APO HUMAN IRE1 ALPHA
Descriptor:Serine/threonine-protein kinase/endoribonuclease IRE1, CESIUM ION, SODIUM ION, ...
Authors:Feldman, H.C., Tong, M., Wang, L., Meza-Acevedo, R., Gobillot, T.A., Gliedt, J.M., Hari, S.B., Mitra, A.K., Backes, B.J., Papa, F.R., Seeliger, M.A., Maly, D.J.
Deposit date:2016-01-08
Release date:2016-06-08
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (2.584 Å)
Cite:Structural and Functional Analysis of the Allosteric Inhibition of IRE1 alpha with ATP-Competitive Ligands.
Acs Chem.Biol., 11, 2016
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