4YBK

C-Helix-Out Dasatinib Analog Crystallized with c-Src Kinase

Summary for 4YBK

Entry DOI	10.2210/pdb4ybk/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide (3 entities in total)
Functional Keywords	protein kinase, c-helix-out, transferase
Biological source	Gallus gallus (Chicken)
Cellular location	Cell membrane : P00523
Total number of polymer chains	1
Total formula weight	33258.27
Authors	Kwarcinski, F.E.,Brandvold, K.B.,Johnson, T.K.,Phadke, S.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. (deposition date: 2015-02-18, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citation	Kwarcinski, F.E.,Brandvold, K.R.,Phadke, S.,Beleh, O.M.,Johnson, T.K.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. Acs Chem.Biol., 11:1296-1304, 2016 Cited by PubMed: 26895387 DOI: 10.1021/acschembio.5b01018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation