4YBK
C-Helix-Out Dasatinib Analog Crystallized with c-Src Kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32726.6 | 1 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | B (A) | 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide | non-polymer | 531.6 | 1 | Chemie (4B7) | |||
| 3 | C (A) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
A: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32726.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 531.6 | |
| All* | Total formula weight | 33258.3 |
