3DQW
c-Src kinase domain Thr338Ile mutant in complex with ATPgS
Summary for 3DQW
| Entry DOI | 10.2210/pdb3dqw/pdb |
| Descriptor | Proto-oncogene tyrosine-protein kinase Src, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | src, kinase, active, gatekeeper, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase |
| Biological source | Gallus gallus (chicken) |
| Cellular location | Cell membrane (By similarity): P00523 |
| Total number of polymer chains | 4 |
| Total formula weight | 133464.91 |
| Authors | Azam, M.,Seeliger, M.A.,Gray, N.,Kuriyan, J.,Daley, G.Q. (deposition date: 2008-07-09, release date: 2008-09-23, Last modification date: 2023-11-15) |
| Primary citation | Azam, M.,Seeliger, M.A.,Gray, N.S.,Kuriyan, J.,Daley, G.Q. Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat.Struct.Mol.Biol., 15:1109-1118, 2008 Cited by PubMed: 18794843DOI: 10.1038/nsmb.1486 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.017 Å) |
Structure validation
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