3DQW

c-Src kinase domain Thr338Ile mutant in complex with ATPgS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1

Chain	Residue
A	ASN391
A	ASP404
A	AGS534
A	HOH717

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 2

Chain	Residue
B	ALA390
B	ASN391
B	AGS534

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 3

Chain	Residue
C	ASN391
C	AGS534

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 4

Chain	Residue
D	ASN391
D	AGS534

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE AGS A 534

Chain	Residue
A	MG1
A	VAL281
A	ALA293
A	LYS295
A	ILE338
A	GLU339
A	MET341
A	SER345
A	ASP386
A	ASN391
A	LEU393
A	ASP404
A	HOH581
A	HOH631
A	HOH659
A	HOH661
A	HOH703
A	HOH717

---

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AGS B 534

Chain	Residue
B	MG2
B	VAL281
B	ALA293
B	LYS295
B	GLU310
B	ILE338
B	GLU339
B	MET341
B	SER345
B	ASN391
B	LEU393
B	ASP404
B	GLY406
B	HOH594
B	HOH699

---

site_id	AC7
Number of Residues	21
Details	BINDING SITE FOR RESIDUE AGS C 534

Chain	Residue
C	MG3
C	LEU273
C	GLY274
C	GLY276
C	PHE278
C	VAL281
C	ALA293
C	LYS295
C	ILE338
C	GLU339
C	MET341
C	SER345
C	LEU393
C	ASP404
C	HOH535
C	HOH570
C	HOH590
C	HOH598
C	HOH620
C	HOH634
C	HOH635

---

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE AGS D 534

Chain	Residue
D	MG4
D	LEU273
D	GLY276
D	PHE278
D	ALA293
D	LYS295
D	ILE338
D	GLU339
D	MET341
D	SER345
D	LEU393
D	ASP404
D	HOH543
D	HOH560
D	HOH573
D	HOH619
D	HOH624

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGCFGEVWmGtwngttr...........VAIK

Chain	Residue	Details
A	LEU273-LYS295

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLRAANILV

Chain	Residue	Details
A	TYR382-VAL394

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"6273838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8856081","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"8856081","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"19948721","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"PubMed","id":"2420005","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP386
A	ALA390

---

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ARG388
B	ASN391
B	ASP386

---

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ARG388
C	ASN391
C	ASP386

---

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ARG388
D	ASN391
D	ASP386

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP386
B	ALA390

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP386
C	ALA390

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP386
D	ALA390

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG388
A	ASP386

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ARG388
B	ASP386

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ARG388
C	ASP386

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ARG388
D	ASP386

---

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG388
A	ASN391
A	ASP386

---