6WIW

c-Src Bound to ATP-Competitive Inhibitor I14

Summary for 6WIW

Entry DOI	10.2210/pdb6wiw/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, N-(3-{[4-amino-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]ethynyl}-4-methylphenyl)acetamide (3 entities in total)
Functional Keywords	complex, inhibitor, kinase, src, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Gallus gallus (Chicken)
Total number of polymer chains	2
Total formula weight	66180.12
Authors	Vilas-Boas, J.,Thakur, M.K.,Fang, L.,Maly, D.,Seeliger, M.A. (deposition date: 2020-04-10, release date: 2020-06-17, Last modification date: 2024-04-03)
Primary citation	Fang, L.,Vilas-Boas, J.,Chakraborty, S.,Potter, Z.E.,Register, A.C.,Seeliger, M.A.,Maly, D.J. How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture. Acs Chem.Biol., 15:2005-2016, 2020 Cited by PubMed: 32479050 DOI: 10.1021/acschembio.0c00429 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation