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2OIQ

Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.

Summary for 2OIQ
Entry DOI10.2210/pdb2oiq/pdb
DescriptorProto-oncogene tyrosine-protein kinase Src, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, ... (4 entities in total)
Functional Keywordssrc, kinase, imatinib, inactive, transferase
Biological sourceGallus gallus (chicken)
Total number of polymer chains2
Total formula weight66131.08
Authors
Seeliger, M.A.,Nagar, B.,Frank, F.,Cao, X.,Henderson, M.N.,Kuriyan, J. (deposition date: 2007-01-11, release date: 2007-03-20, Last modification date: 2023-08-30)
Primary citationSeeliger, M.A.,Nagar, B.,Frank, F.,Cao, X.,Henderson, M.N.,Kuriyan, J.
c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty.
Structure, 15:299-311, 2007
Cited by
PubMed: 17355866
DOI: 10.1016/j.str.2007.01.015
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.07 Å)
Structure validation

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