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5BMM

Src in complex with DNA-templated macrocyclic inhibitor MC25b

Summary for 5BMM
Entry DOI10.2210/pdb5bmm/pdb
Related PRD IDPRD_002183
DescriptorProto-oncogene tyrosine-protein kinase Src, macrocyclic inhibitor MC25b (3 entities in total)
Functional Keywordstransferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceGallus gallus (Chicken)
More
Cellular locationCell membrane : P00523
Total number of polymer chains4
Total formula weight66934.84
Authors
Georghiou, G.,Guja, K.E.,Aleem, S.,Kleiner, R.E.,Liu, D.R.,Miller, W.T.,Garcia-Diaz, M.,Seeliger, M.A. (deposition date: 2015-05-22, release date: 2016-09-21, Last modification date: 2023-11-15)
Primary citationAleem, S.U.,Georghiou, G.,Kleiner, R.E.,Guja, K.E.,Craddock, B.P.,Lyczek, A.,Chan, A.I.,Garcia-Diaz, M.,Miller, W.T.,Liu, D.R.,Seeliger, M.A.
Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.
Cell Chem Biol, 23:1103-1112, 2016
Cited by
PubMed: 27593110
DOI: 10.1016/j.chembiol.2016.07.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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