7KP6
Structure of Ack1 kinase in complex with a selective inhibitor
Summary for 7KP6
Entry DOI | 10.2210/pdb7kp6/pdb |
Descriptor | Activated CDC42 kinase 1, 5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, tyrosine kinase, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 65867.64 |
Authors | Thakur, M.K.,Miller, W.T.,Mahajan, N.,Seeliger, M.A. (deposition date: 2020-11-10, release date: 2022-02-09, Last modification date: 2023-10-25) |
Primary citation | Sridaran, D.,Chouhan, S.,Mahajan, K.,Renganathan, A.,Weimholt, C.,Bhagwat, S.,Reimers, M.,Kim, E.H.,Thakur, M.K.,Saeed, M.A.,Pachynski, R.K.,Seeliger, M.A.,Miller, W.T.,Feng, F.Y.,Mahajan, N.P. Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance. Nat Commun, 13:6929-6929, 2022 Cited by PubMed: 36376335DOI: 10.1038/s41467-022-34724-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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