7KP6
Structure of Ack1 kinase in complex with a selective inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Activated CDC42 kinase 1 | polymer | 287 | 32495.4 | 2 | UniProt (Q07912) Pfam (PF07714) | Homo sapiens (Human) | ACK-1,Tyrosine kinase non-receptor protein 2 |
| 2 | C, F (A, B) | 5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine | non-polymer | 402.9 | 2 | Chemie (WTP) | |||
| 3 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A, B: 110 - 391 (UniProt: Q07912)
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64990.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 876.7 | |
| All* | Total formula weight | 65867.6 |
