6BRJ

DDR1 bound to VX-680

Summary for 6BRJ

• Entry DOI: 10.2210/pdb6brj/pdb
• Descriptor: Epithelial discoidin domain-containing receptor 1, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE (3 entities in total)
• Functional Keywords: kinase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39717.43

Authors

Georghiou, G.,Seeliger, M.A. (deposition date: 2017-11-30, release date: 2018-12-05, Last modification date: 2023-10-25)

• Primary citation: Hanson, S.M.,Georghiou, G.,Thakur, M.K.,Miller, W.T.,Rest, J.S.,Chodera, J.D.,Seeliger, M.A.; What Makes a Kinase Promiscuous for Inhibitors?; Cell Chem Biol, 26:390-399.e5, 2019; PubMed: 30612951; DOI: 10.1016/j.chembiol.2018.11.005

Experimental method

X-RAY DIFFRACTION (2.231 Å)