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4YBJ

Type II Dasatinib Analog Crystallized with c-Src Kinase

Summary for 4YBJ
Entry DOI10.2210/pdb4ybj/pdb
Related4YBK
DescriptorProto-oncogene tyrosine-protein kinase Src, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(3-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-1,3-thiazole-5-carboxamide (3 entities in total)
Functional Keywordsprotein kinase, inactive conformation, transferase
Biological sourceGallus gallus (Chicken)
Cellular locationCell membrane : P00523
Total number of polymer chains2
Total formula weight66706.60
Authors
Kwarcinski, F.E.,Brandvold, K.B.,Johnson, T.K.,Phadke, S.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. (deposition date: 2015-02-18, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citationKwarcinski, F.E.,Brandvold, K.R.,Phadke, S.,Beleh, O.M.,Johnson, T.K.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B.
Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.
Acs Chem.Biol., 11:1296-1304, 2016
Cited by
PubMed: 26895387
DOI: 10.1021/acschembio.5b01018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.61 Å)
Structure validation

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