4YC8

C-Helix-Out Binding of Dasatinib Analog to c-Abl Kinase

Summary for 4YC8

• Entry DOI: 10.2210/pdb4yc8/pdb
• Related: 4YBK
• Descriptor: Tyrosine-protein kinase ABL1, 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-N-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: kinase, c-helix-out, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• Total number of polymer chains: 2
• Total formula weight: 68023.84

Authors

Kwarcinski, F.E.,Brandvold, K.B.,Johnson, T.J.,Phadke, S.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B. (deposition date: 2015-02-19, release date: 2016-03-02, Last modification date: 2023-09-27)

• Primary citation: Kwarcinski, F.E.,Brandvold, K.R.,Phadke, S.,Beleh, O.M.,Johnson, T.K.,Meagher, J.L.,Seeliger, M.A.,Stuckey, J.A.,Soellner, M.B.; Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.; Acs Chem.Biol., 11:1296-1304, 2016; PubMed: 26895387; DOI: 10.1021/acschembio.5b01018

Experimental method

X-RAY DIFFRACTION (2.9 Å)